Visible light-assisted organocatalytic α-acyloxylation of ketones using carboxylic acids and N-halosuccinimides
Visible light-assisted organocatalytic α-acyloxylation of ketones using carboxylic acids and N-halosuccinimides
复制标题
使用羧酸和 N-卤代琥珀酰亚胺对酮进行可见光辅助有机催化 α-酰氧基化
DOI：
10.1039/d2cc04016f
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发表时间：
2022
影响因子：
4.9
通讯作者：
Zhao, John C.-G.
中科院分区：
文献类型：
--
作者：
Sakkani, Nagaraju;Jha, Dhiraj K.;Whatley, Emily;Zhao, John C.-G.
在许多重要的药物和具有生物活性的天然产物及其衍生物中都可以发现α-酰氧基羰基基序。在本论文中，以酮和易得的羧酸为原料，通过光助卤键介导的有机催化α-酰氧基化反应实现了直接合成α-酰氧基酮。以较高的产率获得了理想的α-酰氧基化产物。
The α-acyloxylcarbonyl motif can be found in many important pharmaceuticals and biologically active natural products and their derivatives. In this manuscript, the direct synthesis of α-acyloxylketones from ketones and readily available carboxylic acids was realized using a photo-assisted halogen bond-mediated organocatalytic α-acyloxylation reaction. The desired α-acyloxylation products were obtained in good to high yields.