Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopy
Fish oil supplementation in pregnancy lowers F2-isoprostanes in neonates at high risk of atopy
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DOI：
10.1080/10715760310001656722
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发表时间：
2004-03-01
影响因子：
3.3
通讯作者：
Prescott, SL
中科院分区：
文献类型：
--
作者：
Barden, AE;Mori, TA;Prescott, SL
n-3多不饱和脂肪酸（n-3 PUFA）的抗炎特性表明，这些营养素在预防早期过敏性疾病的饮食调整中具有潜在作用。由于已知氧化应激会改变抗原呈递细胞（APC）信号传导和产生的免疫应答，我们研究了孕期补充n-3多不饱和脂肪酸对过敏高危新生儿氧化应激标志物和APC功能的影响。83名特应性孕妇被随机分为两组，每组40人，每天服用鱼油4g，43人每天服用橄榄油4g。从怀孕20周到分娩的对照试验中服用胶囊。测量血浆（脐带血）和尿F-2-异前列腺素作为脂质过氧化的标志物。测量脐带红细胞脂肪酸和APC功能标志物（HLA-DR表达和细胞因子反应），并与血浆F-2-异前列腺素水平相关。
The anti-inflammatory properties of n-3 polyunsaturated fatty acids (n-3 PUFA) have suggested a potential role of these nutrients in dietary modification for prevention of allergic disease in early life. As oxidative stress is known to modify antigen presenting cell (APC) signalling and resulting immune responses, we examined the effects of maternal n-3 PUFA supplementation in pregnancy on markers of oxidative stress and APC function in neonates at high risk of allergy.Eighty-three pregnant atopic women were randomised to receive 4 g daily of either fish oil ( n =40) or olive oil ( n =43) capsules in a controlled trial from 20 weeks gestation until delivery. Plasma (cord blood) and urinary F-2-isoprostanes were measured as markers of lipid peroxidation. Cord erythrocyte fatty acids and markers of APC function (HLA-DR expression and cytokine responses) were measured and related to levels of plasma F-2-isoprostanes.Maternal fish oil supplementation lowered plasma ( p