Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats
Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats
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DOI：
10.3945/jn.111.157263
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发表时间：
2012-06-01
影响因子：
4.2
通讯作者：
Brown, Lindsay
中科院分区：
文献类型：
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作者：
Panchal, Sunil K.;Poudyal, Hemant;Brown, Lindsay
代谢综合征是心血管疾病和非酒精性脂肪肝（NAFLD）的危险因素。我们研究了雄性Wistar大鼠（8-9周龄）对黄酮醇、槲皮素的反应。两组分别给予富含玉米淀粉（C）或高碳水化合物，高脂肪（H）的饮食16周;其余2组给予C或H饮食8周，然后在随后的8周（分别为CO和HQ）的食物中补充0.8 g/kg槲皮素。H饮食含有类似于68%的碳水化合物，主要是果糖和蔗糖，以及类似于24%的脂肪来自牛脂; C饮食含有类似于68%的碳水化合物多糖和类似于0.7%的脂肪。与C组大鼠相比，H组大鼠体重和腹部肥胖、血脂异常、收缩压升高、糖耐量受损、心血管重构和NAFLD。与C组大鼠相比，H组大鼠核因子（红细胞衍生2）相关因子2（Nrf 2）、血红素加氧酶1（HO-1）和肉毒碱棕榈酰转移酶1（CPT 1）的蛋白表达较低，心脏和肝脏中NF-κ B的表达较高，肝脏中caspase-3的表达较低。HQ大鼠心脏和肝脏中Nrf 2、HO-1和CPT 1的表达均高于H大鼠，而NF-κ B B的表达低于H大鼠。与H大鼠相比，HQ大鼠腹部脂肪较少，收缩压沿着降低，心脏和肝脏的结构和功能变化减弱，尽管H和HQ大鼠之间的体重和血脂异常没有差异。因此，槲皮素治疗减轻了代谢综合征的大部分症状，包括腹部肥胖、心血管重塑和NAFLD，最可能的机制是减少氧化应激和炎症。J.营养142：1026-1032，2012.
Metabolic syndrome is a risk factor for cardiovascular disease and nonalcoholic fatty liver disease (NAFLD). We investigated the responses to the flavonol, quercetin, in male Wistar rats (8-9 wk old) divided into 4 groups. Two groups were given either a corn starch rich (C) or high-carbohydrate, high-fat (H) diet for 16 wk; the remaining 2 groups were given either a C or H diet for 8 wk followed by supplementation with 0.8 g/kg quercetin in the food for the following 8 wk (CO and HQ, respectively). The H diet contained similar to 68% carbohydrates, mainly as fructose and sucrose, and similar to 24% fat from beef tallow; the C diet contained similar to 68% carbohydrates as polysaccharides and similar to 0.7% fat. Compared with the C rats, the H rats had greater body weight and abdominal obesity, dyslipidemia, higher systolic blood pressure, impaired glucose tolerance, cardiovascular remodeling, and NAFLD. The H rats had lower protein expressions of nuclear factor (erythroid-derived 2)-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), and carnitine palmitoyltransferase 1 (CPT1) with greater expression of NF-kappa B in both the heart and the liver and less expression of caspase-3 in the liver than in C rats. HQ rats had higher expression of Nrf2, HO-1, and CPT1 and lower expression of NF-kappa B than H rats in both the heart and the liver. HQ rats had less abdominal fat and lower systolic blood pressure along with attenuation of changes in structure and function of the heart and the liver compared with H rats, although body weight and dyslipidemia did not differ between the H and HQ rats. Thus, quercetin treatment attenuated most of the symptoms of metabolic syndrome, including abdominal obesity, cardiovascular remodeling, and NAFLD, with the most likely mechanisms being decreases in oxidative stress and inflammation. J. Nutr. 142: 1026-1032, 2012.