Tyrosine for depression: a double-blind trial.
Tyrosine for depression: a double-blind trial.
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酪氨酸治疗抑郁症：双盲试验。
DOI：
10.1016/0165-0327(90)90017-3
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发表时间：
1990
影响因子：
6.6
通讯作者：
Mok,GS
中科院分区：
文献类型：
--
作者：
Gelenberg,AJ;Wojcik,JD;Falk,WE;Baldessarini,RJ;Zeisel,SH;Schoenfeld,D;Mok,GS
We treated 65 outpatients with RDC major depression in a randomized, prospective, double-blind comparison of oralL-tyrosine, 100 mg/kg/day, imipramine, 2.5 mg/kg/day, or placebo for 4 weeks. Tyrosine increased and imipramine decreased 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion significantly, but there was no evidence that tyrosine had antidepressant activity. The only side effect to achieve statistical significance was greater dry mouth with imipramine. MHPG excretion and plasma amino acid concentrations failed to predict or correlate with clinical improvement.
