Fever response in old and young mice after injection of interleukin 1.
Fever response in old and young mice after injection of interleukin 1.
复制标题
注射白细胞介素1后老年和年轻小鼠的发烧反应。
DOI：
10.1093/geronj/43.4.m80
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Yoshikawa,TT
中科院分区：
文献类型：
--
作者：
Norman,DC;Yamamura,RH;Yoshikawa,TT
In an attempt to determine why certain elderly humans show a blunted febrile response to infection, a mouse model was developed. Interleukin I (ILI), previously called endogenous pyrogen (EP), the predominantly macrophagederived mediator of fever, was obtained from supernatants that were generated by stimulating macrophages obtained from young and old mice. The dose versus febrile response curves were generated by injecting crude or partially purified supernatants that contained ILI into the tail veins of young and old mice. Old mice responded with less fever than young mice to both crude and partially purified supernatants, suggesting that one mechanism for the blunted fever response observed with aging may be an altered response to EP.
