Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans
Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans
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DOI：
10.1016/j.pbb.2003.08.013
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发表时间：
2003-12-01
影响因子：
3.6
通讯作者：
Foltin, RW
中科院分区：
文献类型：
--
作者：
Collins, ED;Vosburg, SK;Foltin, RW
一些临床研究的数据表明，具有多巴胺激动剂和谷氨酸拮抗剂作用的金刚烷胺可能对治疗可卡因依赖有用。10名可卡因吸食者（7男3女）参与了一项为期26天的住院研究，研究了金刚烷胺和吸食可卡因之间的相互作用。在实验室测试前，参与者使用金刚烷胺（0和100mg bid）维持5天，采用双盲交叉设计。在每一种药物条件下，参与者吸食一次样品剂量的可卡因碱（0、12、25和50毫克），随后有5次选择机会，间隔14分钟，自行服用该剂量的可卡因或获得商品代金券（5美元）。每种给药条件下，每个可卡因剂量检测2次，且给药条件和可卡因剂量顺序有系统变化。可卡因产生类似兴奋剂的强化、主观和生理效应。金刚烷胺维持治疗并没有改变自行吸食可卡因的选择。这些发现，连同其他混杂的文献，表明金刚烷胺（100mg bid）在治疗可卡因依赖中没有作用。(C) 2003 Elsevier Inc.版权所有。
Data from several clinical studies have suggested that amantadine, which has dopaminergic agonist and glutamatergic antagonist effects, may be useful for the treatment of cocaine dependence. The interaction between amantadine and smoked cocaine was examined in 10 cocaine smokers (7 men, 3 women), who participated in a 26-day inpatient study. Participants were maintained on amantadine (0 and 100 mg bid) for 5 days prior to laboratory testing, using a double-blind crossover design. Under each medication condition, participants smoked a sample dose of cocaine base (0, 12, 25, and 50 mg) once, and were subsequently given five choice opportunities, 14 min apart, to self-administer that dose of cocaine or receive a merchandise voucher ($5.00). Each cocaine dose was tested twice under each medication condition, and the order of medication condition and cocaine dose varied systematically. Cocaine produced stimulant-like reinforcing, subjective, and physiological effects. Amantadine maintenance did not modify the choice to self-administer smoked cocaine. These findings, taken together with the decidedly mixed literature, suggest that amantadine (100 mg bid) will not have a role in the treatment of cocaine dependence. (C) 2003 Elsevier Inc. All rights reserved.