Bioactive Materials for Regenerative Medicine: Zeolite-Hydroxyapatite Bone Mimetic Coatings
Bioactive Materials for Regenerative Medicine: Zeolite-Hydroxyapatite Bone Mimetic Coatings
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DOI：
10.1002/adem.201100170
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发表时间：
2012-03-01
影响因子：
3.6
通讯作者：
Yan, Yushan S.
中科院分区：
文献类型：
--
作者：
Bedi, Rajwant Singh;Chow, Gabriel;Yan, Yushan S.
本文报道了钛合金和不锈钢表面新型沸石-羟基磷灰石复合涂层的合成和表征。沸石-羟基磷灰石涂层具有超亲水性，在腐蚀性点蚀NaCl介质、含BSA蛋白的磷酸盐缓冲溶液以及高度复杂的DMEM细胞培养基中的耐腐蚀性测试中，其性能优于最先进的Ti6 Al 4V合金。复合涂层还消除了涂层与骨之间的弹性模量失配。此外，复合涂层对hFOB具有骨传导和骨诱导作用，表明其可以增强植入物的骨整合并加速术后恢复，从而减少对复发性植入物置换手术的需求。用沸石-羟基磷灰石涂层钢代替钛还可以显著降低植入物成本，同时延长植入物寿命。
We report the synthesis and characterization of a novel zeolite-hydroxyapatite composite coating on titanium alloys and stainless steel. The zeolite-hydroxyapatite coating is superhydrophilic and outperforms the state-of-the-art Ti6Al4V alloys in corrosion resistance tests in aggressive pitting NaCl media, phosphate buffer solution with BSA protein, as well as highly complex DMEM cell culture media. And the composite coating also eliminates the elastic modulus mismatch between coating and bone. In addition, the composite coating has an osteoconductive and osteoinductive effect on hFOBs, indicating that it may enhance osteointegration of implants and speed up post-surgical recovery, and thus reduce the need for recurring implant replacement surgeries. Replacing titanium with zeolite-hydroxyapatite coated steel can also significantly reduce implant cost while improving implant lifespan.