Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology
Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology
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DOI：
10.1016/j.neulet.2013.07.016
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发表时间：
2013-09-13
影响因子：
2.5
通讯作者：
Letournel, Franck
中科院分区：
文献类型：
--
作者：
Folgoas, Emmanuelle;Lebouvier, Thibaud;Letournel, Franck
最近帕金森病（PD）患者的下颌下腺存在Lewy病理学的证据促使我们评估小唾液腺活检对PD的诊断性能。在16例临床诊断为PD的患者和11例其他神经系统疾病的对照受试者中，使用磷酸化α-突触核蛋白抗体检查小唾液腺的Lewy病理学。16例PD患者中有3例发现α-突触核蛋白异常蓄积。两名对照受试者表现出弱磷酸化α-突触核蛋白免疫反应性。我们的研究结果不支持使用小唾液腺活检检测活体受试者的Lewy病理。(C)2013爱思唯尔爱尔兰有限公司版权所有。
The recent demonstration of the presence of Lewy pathology in the submandibular glands of Parkinson's disease (PD) patients prompted us to evaluate the diagnostic performance of minor salivary gland biopsy for PD. Minor salivary glands were examined for Lewy pathology using phosphorylated alpha-synuclein antibody in 16 patients with clinically diagnosed PD and 11 control subjects with other neurological disorders. Abnormal accumulation of alpha-synuclein was found in 3 out of 16 PD patients. Two control subjects exhibited weak phosphorylated alpha-synuclein immunoreactivity. Our results do not support the use of minor salivary glands biopsy for the detection of Lewy pathology in living subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.