Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial
Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial
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含有假神经酰胺和桉树提取物的保湿霜对成人特应性皮炎出汗功能的影响：双盲、随机、对照左右比较临床试验
DOI：
10.1111/jocd.14923
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
et al. Among authors: katayama i.
中科院分区：
文献类型：
--
作者：
Shindo S;et al. Among authors: katayama i.
研究背景：特应性皮炎（AD）患者出汗能力下降。有几个因素可以导致排汗减少，例如汗管的紧密连接薄弱，乙酰胆碱受体功能降低，以及组胺对排汗的抑制。AD皮肤的角化不全也通过阻塞毛孔来减少出汗。角质层中神经酰胺水平的增加通过改善角质层功能来减少角化不全。此外，神经酰胺和/或神经酰胺衍生物可能影响claudin-3和乙酰胆碱受体。我们研究了含有伪神经酰胺和桉树提取物的保湿霜增加表皮中神经酰胺水平以改善AD患者出汗能力的功效。一天4周。皮肤状况和出汗能力，作为对乙酰胆碱刺激的反应，在研究开始前（第0周）和第2周和第4周结束时进行评价。结果两种保湿剂都改善了视觉评价的皮肤症状和皮肤水合作用。然而，只有含有伪神经酰胺和桉树提取物的保湿剂显著改善了皮肤屏障功能，并显著增加了角质层中的神经酰胺水平。该保湿霜还增加了出汗量，缩短了出汗的潜伏时间，这是出汗能力的指标，但其他保湿霜没有。结论基于这些结果，含有伪神经酰胺和桉树提取物的保湿霜有助于恢复AD患者的出汗功能。
BackgroundMany patients with atopic dermatitis (AD) have a decreased ability to sweat. Several factors can cause decreased perspiration, such as weak tight junctions of sweat ducts, reduced acetylcholine receptor function, and inhibition of perspiration by histamines. Parakeratosis of AD skin also decreases sweating by occluding sweat pores. Increased ceramide levels in the stratum corneum reduce parakeratosis by improving stratum corneum functions. Furthermore, ceramides and/or ceramide derivatives may affect claudin‐3 and acetylcholine receptors.ObjectiveIn this study, we investigated the efficacy of a moisturizer containing pseudo‐ceramide and a eucalyptus extract to increase ceramide levels in the epidermis to improve the sweating ability of patients with AD.MethodsNineteen patients with AD applied moisturizers with or without pseudo‐ceramide and a eucalyptus extract on the cubital fossa of either arm twice a day for 4 weeks. Skin conditions and sweating ability, measured as the response to acetylcholine stimulation, were evaluated prior to the start of the study (Week 0) and at the end of Weeks 2 and 4.ResultsBoth moisturizers improved the visually evaluated skin symptoms and skin hydration. However, only the moisturizer containing pseudo‐ceramide and the eucalyptus extract significantly improved cutaneous barrier function and significantly increased the ceramide level in the stratum corneum. That moisturizer also increased the sweating volume and shortened the latency time for sweating, an indicator of sweating ability, but the other moisturizer did not.ConclusionBased on these results, the moisturizer containing pseudo‐ceramide and a eucalyptus extract helps recover the sweat function of AD patients.