Association between clinical symptoms and post‐mortem neuropathology in dementia with Lewy bodies
Association between clinical symptoms and post‐mortem neuropathology in dementia with Lewy bodies
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路易体痴呆临床症状与死后神经病理学之间的关联
DOI：
10.1111/ggi.13853
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发表时间：
2020
影响因子：
3.3
通讯作者：
Hanyu Haruo
中科院分区：
文献类型：
--
作者：
Kaneko Yoshitsugu;Hirao Kentaro;Serisawa Shuntaro;Kanetaka Hidekazu;Shimizu Soichiro;Hirai Hideaki;Shishido‐Hara Yukiko;Umahara Takahiko;Sakurai Hirofumi;Hanyu Haruo
我们报告一个87岁的男性病例，临床诊断为可能的DLB，尸检证实为明确的DLB。大约在他去世前5年，他的妻子注意到他大声说话，在睡觉时拍打他的上肢/下肢，从而被诊断为快速眼动行为障碍（RBD）。大约3年前，患者出现健忘，1.5年前，患者偶尔出现视幻觉，如在天花板上看到昆虫，其简易精神状态检查得分为26分。神经学检查未见帕金森病，包括肌肉强直、震颤、肢体麻痹及直立性低血压等自主神经异常。脑灌注单光子发射计算机断层显示双侧颞顶叶/内侧枕叶明显灌注不足。磁共振成像未见脑梗死或海马萎缩。（123） i -甲氧十二苄基胍显像显示心脏明显减少。
We report a case of an 87-year-old man, clinically diagnosed as probable DLB and confirmed as definite DLB on autopsy. Approximately 5 years before his death, his wife noticed that he talked loudly and flapped his upper/lower limbs during his sleep, leading to a diagnosis of rapid eye movement behavior disorder (RBD). Approximately 3 years previously, the patient had noticed forgetfulness, and 1.5 years previously, he recognized occasional visual hallucinations, such as seeing insects on the ceiling, and his Mini-Mental State Examination score was 26. Neurological examination showed no parkinsonism, including muscle rigidity, tremor, limb paralysis and dysautonomia, such as orthostatic hypotension. Brain perfusion single-photon emission computed tomography showed significant hypoperfusion in the bilateral temporoparietal/medial occipital lobes. There were no cerebral infarctions or hippocampal atrophy on magnetic resonance imaging.(123) I-metaiodobenzylguanidine scintigraphy showed a significant reduction in the heart.