Liphagal, a selective inhibitor of PI3 kinase α isolated from the sponge Aka coralliphaga:: Structure elucidation and biomimetic synthesis
Liphagal, a selective inhibitor of PI3 kinase α isolated from the sponge Aka coralliphaga:: Structure elucidation and biomimetic synthesis
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DOI：
10.1021/ol052744t
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发表时间：
2006-01-19
期刊：
影响因子：
5.2
通讯作者：
Andersen, RJ
中科院分区：
文献类型：
--
作者：
Marion, F;Williams, DE;Andersen, RJ
Lipagal（1）是一种PI3K α的选择性抑制剂，已从多米尼加采集的海洋海绵Aka coralliphaga中分离出来。liphagal（1）的“liphagane”部分萜碳骨架是新的。仿生全合成已被用于证实liphagal的构成（1），并支持提出的生物发生。
Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the constitution of liphagal (1) and support a proposed biogenesis.