HDL-inflammatory index correlates with poor outcome in hemodialysis patients
HDL-inflammatory index correlates with poor outcome in hemodialysis patients
复制标题
DOI：
10.1038/sj.ki.5002491
复制
发表时间：
2007-11-01
影响因子：
19.6
通讯作者：
Navab, M.
中科院分区：
文献类型：
--
作者：
Kalantar-Zadeh, K.;Kopple, J. D.;Navab, M.
氧化应激和心血管疾病是慢性肾脏病(CKD)维持性血液透析的危险因素。我们使用低密度脂蛋白的荧光作为其促炎潜能的指标，以检查高密度脂蛋白(HDL)在促进这一效应方面可能起到的任何作用。用近红外仪测量患者的体脂总量，用SF36问卷测量患者的生活质量。在189名随机选择的患者中，跟踪观察30个月，发现高密度脂蛋白具有显著的抗炎作用，但标准差很大。足足有17%的患者有明确的促炎指数和较差的SF36评分。患者按体脂百分比分为10%递增至40%。研究发现，体内脂肪含量越高，高密度脂蛋白越容易引发炎症。与那些高密度脂蛋白抗炎的患者相比，高密度脂蛋白致炎指数较高的患者30个月的调整后死亡风险比更高。我们的研究结果提示炎症高密度脂蛋白在慢性肾脏病患者中起着重要作用，导致不良预后。
Oxidative stress and cardiovascular disease are risk factor of patients with chronic kidney disease (CKD) on maintenance hemodialysis. We used the fluorescence of low-density lipoprotein as an index of its proinflammatory potential to examine any role that high-density lipoprotein (HDL) might have in promoting this effect. The total body fat of the patients was measured by means of near-infrared interactance and their quality of life by means of SF36 questionnaires. In 189 randomly selected patients, followed for 30 months, HDL was found to be significantly antiinflammatory but with a large standard deviation. Fully 17% of the patients had a decidedly proinflammatory index along with inferior SF36 scores. The patients were divided into 10% increments of total body fat percentages up to 40%. HDL was found to be progressively proinflammatory the higher the body fat content. Patients with a higher HDL proinflammatory index had a higher 30-month adjusted hazard ratio for death than those whose HDL were seen to be anti-inflammatory. Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome.