An efficient two-stage approach for image-based FSI analysis of atherosclerotic arteries.
An efficient two-stage approach for image-based FSI analysis of atherosclerotic arteries.
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DOI：
10.1007/s10237-009-0172-3
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发表时间：
2010-04
影响因子：
3.5
通讯作者：
Saloner, David
中科院分区：
文献类型：
--
作者：
Leach, Joseph R.;Rayz, Vitaliy L.;Mofrad, Mohammad R. K.;Saloner, David
关键词：
动脉粥样硬化动脉的患者特定生物力学建模有可能帮助临床医生描述病变特征并确定最佳治疗计划。为了获得高水平的准确性，最近的模型使用医学成像数据来确定三维斑块成分边界，并且使用流体-结构相互作用来捕获患病血管的机械载荷。由于斑块成分和血管壁的形状通常非常复杂，因此构建合适的结构化计算网格非常具有挑战性，并且可能需要大量时间。基于非结构化计算网格的模型需要相对较少的时间来构建，并且能够在三维中准确地表示斑块成分。不幸的是，这些模型需要额外的计算资源和计算时间来获得准确和有意义的结果。提出了一种基于非结构化计算网格的两阶段建模策略，以实现网格划分难度与计算资源和时间需求之间的合理平衡。在该方法中，全动脉域的粗粒度模拟用于引导和约束全域内较小感兴趣区域的细尺度模拟。一个病人特定的颈动脉分叉模型的结果表明，两阶段的方法可以提供一个大的节省时间的网格生成和计算所需的时间和资源。固体和流体域截断的影响进行了探讨，并显示出最小的影响与两阶段的方法预测的应力场的准确性。
Patient-specific biomechanical modeling of atherosclerotic arteries has the potential to aid clinicians in characterizing lesions and determining optimal treatment plans. To attain high levels of accuracy, recent models use medical imaging data to determine plaque component boundaries in three dimensions, and fluid–structure interaction is used to capture mechanical loading of the diseased vessel. As the plaque components and vessel wall are often highly complex in shape, constructing a suitable structured computational mesh is very challenging and can require a great deal of time. Models based on unstructured computational meshes require relatively less time to construct and are capable of accurately representing plaque components in three dimensions. These models unfortunately require additional computational resources and computing time for accurate and meaningful results. A two-stage modeling strategy based on unstructured computational meshes is proposed to achieve a reasonable balance between meshing difficulty and computational resource and time demand. In this method, a coarsegrained simulation of the full arterial domain is used to guide and constrain a fine-scale simulation of a smaller region of interest within the full domain. Results for a patient-specific carotid bifurcation model demonstrate that the two-stage approach can afford a large savings in both time for mesh generation and time and resources needed for computation. The effects of solid and fluid domain truncation were explored, and were shown to minimally affect accuracy of the stress fields predicted with the two-stage approach.
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影响因子：
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