Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits-A SPECT study
Oxytocin receptor gene rs53576 polymorphism modulates oxytocin-dopamine interaction and neuroticism traits-A SPECT study
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DOI：
10.1016/j.psyneuen.2014.05.020
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发表时间：
2014-09-01
影响因子：
3.7
通讯作者：
Chen, Po See
中科院分区：
文献类型：
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作者：
Chang, Wei Hung;Lee, I. Hui;Chen, Po See
大脑催产素和多巴胺系统相互作用来调节社会认知行为。这种相互作用是否受到催产素受体（OXTR）基因变异的调节仍不清楚。考虑到多巴胺转运蛋白（DAT）可用性作为内表型以及多巴胺介导的神经质程度作为OXTR基因型的表型，当前的分子影像研究使用[Tc-99m]TRODAT-1单光子发射计算机断层扫描（SPECT）来测量纹状体DAT可用性和57项Maudsley人格量表来测量健康个体的神经质人格特征来研究(A) OXTR rs53576 (G/A) 与纹状体 DAT 可用性之间的相关性，(B) 不同 OXTR rs53576 (G/A) 基因型之间外周催产素水平与纹状体 DAT 可用性之间的相关性，以及 (C) 某些 OXTR rs53576 基因型中的神经质特征是否可以被催产素改变。结果显示，AG + GG 组的纹状体 DAT 可用性显着低于 AA 组（2.08 +/- 0.47 vs. 1.90 +/- 0.32，p = 0.04）。只有具有一两个 rs53576 G 等位基因拷贝的个体才显示 DAT 可用性和催产素水平之间呈负相关（r = 0.41，p = 0.002）。此外，在 AA 组中，催产素 x DAT 相互作用与 MPI 神经质评分显着相关。进一步分析表明，仅在催产素水平较低的 AA 组中，DAT 可用性与神经质评分相关（r = 0.74，p = 0.002）。结果表明，OXTR rs53576 与体内纹状体 DAT 可用性相关，并调节催产素能系统和多巴胺能系统之间的相互作用。具有特定rs53576 OXTR基因型的携带者可能在环境适应方面表现出更高的生物敏感性和应激反应性。 (C) 2014 年，爱思唯尔有限公司出版。
Brain oxytocin and dopamine systems interact to modulate social cognitive behavior. Whether the interactions are modulated by oxytocin receptor (OXTR) gene variations remains unclear. Considering the dopamine transporter (DAT) availability as an endophenotype and the degree of dopamine-mediated neuroticism as a phenotype of the OXTR genotypes, the current molecular imaging study used [Tc-99m]TRODAT-1 single photon emission computed tomography (SPECT) to measure the striatal DAT availability and the 57-item Maudsley Personality Inventory to measure neuroticism personality traits in healthy individuals to investigate (A) the correlation between the rs53576 (G/A) of OXTR and the striatal DAT availability, (B) the correlation between the peripheral oxytocin level and striatal DAT availability among different OXTR rs53576 (G/A) genotypes, and (C) whether neuroticism traits could be modified by oxytocin in certain OXTR rs53576 genotypes. The results showed that the striatal DAT availability in the AG + GG group was significantly lower than that in the AA group (2.08 +/- 0.47 vs. 1.90 +/- 0.32, p = 0.04). Only individuals with one or two copies of the G allele of rs53576 showed a negative correlation between DAT availability and oxytocin level (r = 0.41, p = 0.002). Furthermore, the oxytocin x DAT interaction was significantly correlated with the MPI neuroticisnn score in the AA group. Further analyses showed that the DAT availability was correlated with the neuroticism score only in the AA group with a low oxytocin level (r = 0.74, p = 0.002). The results indicated that the OXTR rs53576 is connected with the striatal DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems. Carriers with a specific rs53576 OXTR genotype may present a greater biological sensitivity as well as stress reactivity in terms of environmental adaptation. (C) 2014 Published by Elsevier Ltd.