Effect of aging on vasopressin and aquaporin responses to dehydration in Fischer 344-brown-Norway F1 rats.
Effect of aging on vasopressin and aquaporin responses to dehydration in Fischer 344-brown-Norway F1 rats.
复制标题
衰老对 Fischer 344-brown-Norway F1 大鼠脱水反应的加压素和水通道蛋白的影响。
DOI：
10.1152/ajpregu.1997.273.1.r35
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Sladek,CD
中科院分区：
文献类型：
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作者：
Swenson,KL;Sands,JM;Jacobs,JD;Sladek,CD
与4月龄大鼠相比，30月龄Fischer 344（F344）大鼠对72 h禁水的血浆加压素（VP）反应减弱。这似乎反映了不能增加VP合成。相比之下，在Brown-Norway（BN）品系大鼠中报告了继发于肾VP反应性降低的血浆VP升高。评价了这些菌株（F344 BNF 1）的F1杂交对脱水的反应。雄性大鼠，4月龄和30月龄，被剥夺了水72小时或允许自由饮水。青年和老年大鼠脱水后血浆钠和红细胞压积均显著升高（P < 0.05），而血浆VP、尿渗透压和水通道蛋白2表达仅青年大鼠升高（P < 0.05）。垂体后叶的VP免疫反应的内容是耗尽的年轻，但不是老年大鼠。因此，老年F344 BNF 1大鼠表现出一个赤字VP释放响应一个明显类似的脱水刺激。这一缺陷与先前报道的F344或BN菌株的缺陷不同。因此，需要进一步的研究，以确定这种反应的异常。
The plasma vasopressin (VP) response to 72 h of water deprivation is attenuated in 30-mo-old Fischer 344 (F344) rats relative to 4-mo-old rats. This appears to reflect an inability to increase VP synthesis. In contrast, elevated plasma VP has been reported in the Brown-Norway (BN) strain of rats secondary to reduced renal VP responsivity. The response to dehydration in the F1 cross of these strains (F344BNF1) was evaluated. Male rats, 4 and 30 mo old, were deprived of water for 72 h or allowed water ad libitum. In response to dehydration, plasma sodium and hematocrit were significantly increased in both young and aged rats (P < 0.05), but plasma VP, urine osmolality, and aquaporin 2 expression were only increased in the young rats (P < 0.05). Posterior pituitary content of immunoreactive VP was depleted in the young but not the old rats. Thus the aged F344BNF1 rats demonstrated a deficit in VP release in response to an apparently similar dehydration stimulus. This deficit was different from those previously reported for either the F344 or BN strains. Thus further studies are required to determine the abnormalities underlying this response.