Diagnostic value of contrast-enhanced fluid-attenuated inversion-recovery and delayed contrast-enhanced brain MRI in multiple sclerosis
Diagnostic value of contrast-enhanced fluid-attenuated inversion-recovery and delayed contrast-enhanced brain MRI in multiple sclerosis
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DOI：
10.1016/j.acra.2007.07.022
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发表时间：
2008-01-01
影响因子：
4.8
通讯作者：
Nikseresht, Alireza R.
中科院分区：
文献类型：
--
作者：
Bagheri, Mohammad Hadi;Meshksar, Arash;Nikseresht, Alireza R.
基本原理和目标。在多发性硬化症 (MS) 患者的脑 MRI 中，通常在早期对比增强 T1 加权图像 (CE-T1WI) 中评估病变的增强情况。本研究的目的是确定对比增强液体衰减反转恢复 (CE-FLAIR) 和延迟对比增强 MRI 在评估多发性硬化症脑损伤中的敏感性。材料和方法。对 46 名临床明确的多发性硬化症患者进行了脑部 MRI 检查，包括早期和延迟的 CE-T1WI 以及早期和延迟的 CE-FLAIR 图像。分别记录每个序列中强化病灶的数量、大小、位置、程度和强化模式。结果。 30例患者共检测到87个强化病灶。早期CE-T1WI只能检测到24名患者的63个病灶（占总数的72.4%），而延迟CE-T1WI和早期和延迟CE-FLAIR图像分别显示28、28和26名患者的85（97.7%）、84（96.6%）和81（93.1%）病灶。与早期CE-T1WI相比，附加序列中观察到更大程度的强化和更大的病灶尺寸。结论。早期CE-T1WI检测增强MS病变的敏感性明显低于其他附加序列。延迟的 CE-FLAIR 图像无法向其他序列添加重要信息。因此，早期CE-FLAIR和延迟CE-T1WI脑MRI可以考虑作为MS患者评估的一部分，特别是如果尽管临床怀疑有活动性疾病，但常规CE-T1WI未发现强化病灶。
Rationale and Objectives. In brain MRI of multiple sclerosis (MS) patients, enhancement of the lesions is usually evaluated in early contrast-enhanced T1-weighted images (CE-T1WI). The objective of this study is to determine the sensitivity of contrast-enhanced fluid-attenuated-inversion-recovery (CE-FLAIR) and delayed contrast-enhanced MRI in evaluation of MS brain lesions.Materials and Methods. Brain MRI examination including early and delayed CE-T1WI and early and delayed CE-FLAIR images was performed for 46 patients with clinically definite MS disease. Number, size, location, degree, and pattern of enhancement of the enhanced lesions in each sequence were recorded separately.Results. A total number of 87 enhanced lesions was detected in 30 patients. Early CE-T1WI could detect only 63 lesions (72.4% of total) in 24 patients, while delayed CE-T1WI and early and delayed CE-FLAIR images showed 85 (97.7%), 84 (96.6%), and 81 (93.1%) lesions in 28, 28, and 26 patients, respectively. A greater degree of enhancement and larger lesion size were observed in the additional sequences compared with the early CE-T1WI.Conclusions. The sensitivity of early CE-T1WI for the detection of enhanced MS lesions is significantly lower than that for other additional sequences. Delayed CE-FLAIR images could not add significant information to other sequences. Therefore, early CE-FLAIR and delayed CE-T1WI brain MRI can be considered as part of the evaluation of MS patients, especially if, despite clinically suspected active disease, no enhanced lesion is found in the routine CE-T1WI.