Predictors and Consequences of Global DNA Methylation in Cord Blood and at Three Years
Predictors and Consequences of Global DNA Methylation in Cord Blood and at Three Years
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DOI：
10.1371/journal.pone.0072824
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发表时间：
2013-09-04
期刊：
影响因子：
3.7
通讯作者：
Tang, Deliang
中科院分区：
文献类型：
--
作者：
Herbstman, Julie B.;Wang, Shuang;Tang, Deliang
DNA 甲基化变化与许多常见的慢性疾病有关，因此人们假设个体内与环境和年龄相关的 DNA 甲基化变化与疾病病因有关。很少有研究检查个体体内 DNA 甲基化随时间的变化，并且所有这些研究都是在成年人中进行的。在这里，我们的目标是在纵向出生队列研究中描述从出生到三岁的全球 DNA 甲基化如何变化，并确定是否存在相隔三年测量的 DNA 甲基化水平的一致预测因子。我们使用免疫测定法测量了 165 名儿童在出生时（脐带血）和三岁时的整体 DNA 甲基化情况。我们发现，平均而言，3 岁时血液中的 DNA 甲基化显着高于脐带血 (p
DNA methylation changes have been implicated in many common chronic diseases leading to the hypothesis that environmental and age-related DNA methylation changes within individuals are involved in disease etiology. Few studies have examined DNA methylation changes within an individual over time and all of these studies have been conducted in adults. Here, we aim to characterize how global DNA methylation changes from birth to age three within a longitudinal birth cohort study and to determine whether there are consistent predictors of DNA methylation levels measured three years apart. We measured global DNA methylation in the same children at birth (cord blood) and again at three years of age among 165 children, using an immunoassay. We found that on average, DNA methylation was significantly higher in blood at age 3-years than in cord blood (p