Secondary Effects from Mass Azithromycin Administration: A Systematic Review and Meta-analysis
Secondary Effects from Mass Azithromycin Administration: A Systematic Review and Meta-analysis
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DOI：
10.4269/ajtmh.22-0134
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Dezhi Mu
中科院分区：
文献类型：
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作者：
Jinhui Li;Tao Xiong;Yan Yue;Imti Choonara;Shamim Qazi;Jun Tang;Jing Shi;Hua Wang;Yi Qu;Dezhi Mu
The effects of azithromycin mass drug administration (MDA) on trachoma and yaws have been addressed. However, the secondary effects of azithromycin MDA remain unclear. This study aimed to explore the secondary effects of azithromycin MDA. PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov were searched from conception to January 5, 2022. Studies on secondary effects of azithromycin MDA were included. A total of 34 studies were included. Six of them reported on child mortality, 10 on malaria, and 20 on general morbidity and condition. Azithromycin MDA reduced child mortality, and quarterly MDA may be most beneficial for reducing child mortality. The effect of azithromycin MDA on malaria was weak. No association was observed between azithromycin MDA and malaria parasitemia (rate ratio: 0.71, 95% confidence interval: 0.43–1.15). Azithromycin MDA was associated with a lower risk of respiratory tract infections and diarrhea. Additionally, it was associated with a lower risk of fever, vomiting, and headache. The carriage of pathogenic organisms such as Streptococcus pneumoniae and gut Campylobacter species was reduced. However, these secondary effects of azithromycin MDA appeared to last only a few weeks. Moreover, no association was observed between azithromycin MDA and nutritional improvement in children. In conclusion, azithromycin MDA had favorable secondary effects on child mortality and morbidity. However, the effects were short term.
