Graphene oxide/hydroxyapatite composite coatings fabricated by electrophoretic nanotechnology for biological applications
Graphene oxide/hydroxyapatite composite coatings fabricated by electrophoretic nanotechnology for biological applications
复制标题
电泳纳米技术制备氧化石墨烯/羟基磷灰石复合涂层的生物应用
DOI：
10.1016/j.carbon.2013.09.080
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发表时间：
2014-02-01
期刊：
影响因子：
10.9
通讯作者：
Wei, Shicheng
中科院分区：
文献类型：
--
作者：
Li, Ming;Liu, Qian;Wei, Shicheng
首次采用阴极电泳法在羟基磷灰石(HA)涂层中加入氧化石墨烯(GO)作为纳米增强填料，在纯钛衬底上制备了GO/HA涂层。对悬浮液的透射电子显微镜观察和粒度分析表明，HA纳米颗粒均匀分布在GO片上，形成了较大的GO/HA颗粒群。在HA涂层中加入GO可以减少涂层表面裂纹，使涂层结合强度从1.55+/-0.39 Mpa(纯HA)提高到2.75+/-0.38 Mpa(2wt.%Go/HA)和3.3+/-0.25 Mpa(5wt.%Go/HA)。动电位极化和交流阻抗谱研究表明，与纯HA涂层相比，GO/HA复合涂层在模拟体液中具有更好的耐蚀性。此外，与羟基磷灰石涂层和未涂层钛基质相比，具有更好的体外生物相容性(约95%的细胞存活率为2wt.%GO/HA)或类似的(细胞存活率为80-90%的5wt.%GO/HA)。(C)2013爱思唯尔有限公司。保留所有权利。
Graphene oxide (GO) was firstly employed as nanoscale reinforcement fillers in hydroxyapatite (HA) coatings by a cathodic electrophoretic deposition process, and GO/HA coatings were fabricated on pure Ti substrate. The transmission electron microscopy observation and particle size analysis of the suspensions indicated that HA nanoparticles were uniformly decorated on GO sheets, forming a large GO/HA particle group. The addition of GO into HA coatings could reduce the surface cracks and increase the coating adhesion strength from 1.55 +/- 0.39 MPa (pure HA) to 2.75 +/- 0.38 MPa (2 wt.% GO/HA) and 3.3 +/- 0.25 MPa (5 wt.% GO/HA), respectively. Potentiodynamic polarization and electrochemical impedance spectroscopy studies indicated that the GO/HA composite coatings exhibited higher corrosion resistance in comparison with pure HA coatings in simulated body fluid. In addition, superior (around 95% cell viability for 2 wt.% GO/HA) or comparable (80-90% cell viability for 5 wt.% GO/HA) in vitro biocompatibility were observed in comparison with HA coated and uncoated Ti substrate. (C) 2013 Elsevier Ltd. All rights reserved.