HORMONAL STATE AFFECTS RECOVERY FROM FRONTAL-CORTEX LESIONS IN ADULT FEMALE RATS
HORMONAL STATE AFFECTS RECOVERY FROM FRONTAL-CORTEX LESIONS IN ADULT FEMALE RATS
复制标题
DOI：
10.1016/s0163-1047(87)90918-6
复制
发表时间：
1987-11-01
期刊：
影响因子：
--
通讯作者：
STEIN, DG
中科院分区：
文献类型：
--
作者：
ATTELLA, MJ;NATTINVILLE, A;STEIN, DG
对假孕和正常骑行的雌性SD大鼠进行延迟空间交替任务训练。在获得训练后，受试者接受额叶皮质损伤，随后进行保持测试。有损伤的假孕动物比正常骑自行车的动物受到的损害更小。在非损伤对照组中，学习和保持测试不受激素状态的影响。组织学检查显示，额叶皮质损伤的正常骑行大鼠脑室增大，表明该手术组存在水肿。然而，假孕受试者给予相同的损伤和两种激素状态的假手术的脑组织并没有表现出这种水肿的特征。我们推测，在患有脑损伤的正常骑行女性中观察到的行为和解剖损伤是由于加压素水平较高，在我们的操作中，加压素是一种与脑损伤同步的有效血管收缩因子。
Pseudopregnant and normal cycling female Sprague-Dawley rats were trained on a delayed-spatial alternation task. After acquisition training, the subjects received frontal cortex lesions and were subsequently tested for retention. The pseudopregnant animals with lesions were less impaired than their normal cycling counterparts. Learning and retention testing were not affected by hormonal status in the noninjured controls. Histological examination showed that the normal cycling rats with frontal cortex lesions possessed enlarged ventricles, indicating the presence of edema in this surgical group. However, brain tissue of pseudopregnant subjects given the same lesion and sham operates of both hormonal states did not display this characteristic of edema. We speculate that the behavioral and anatomical impairment observed in the normal cycling females with brain injury is due to higher levels of vasopressin, a potent vasoconstrictor synchronized with brain injury in our manipulation.