Helicobacter pylori IgA and IgG antibodies, serum pepsinogen I and the risk of gastric cancer: Changes in the risk with extended follow-up period
Helicobacter pylori IgA and IgG antibodies, serum pepsinogen I and the risk of gastric cancer: Changes in the risk with extended follow-up period
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DOI：
10.1002/ijc.21884
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发表时间：
2006-08-01
影响因子：
6.4
通讯作者：
Kosunen, Timo U.
中科院分区：
文献类型：
--
作者：
Knekt, Paul;Teppo, Lyly;Kosunen, Timo U.
在一项巢式病例对照研究中，研究了幽门螺杆菌抗体免疫球蛋白A（伊加）、免疫球蛋白G（IgG）和血清胃蛋白酶原I（PG 1）对胃癌发生的预测作用，该研究基于1966-1991年芬兰队列随访的225例新发癌症病例和435例匹配对照。感染者和非感染者非贲门部胃癌的优势比分别为伊加升高3.12（95%可信区间（0）= 1.97-4.95）和IgG抗体升高2.88（CI：1.63-5.07）。低与高PG I之间的比值比为2.24（CI：1.43-3.49）。在整个随访期间，伊加抗体的相关性强度显著，但IgG抗体仅在15年或更长的随访期内才如此。伊加抗体与除肠型腺癌外的所有登记的组织学亚型显著相关。与两种抗体均阴性且PIG I正常的个体相比，伊加和IgG抗体同时升高且PG I低的个体胃癌风险最高，比值比为10.9（CI：4.31-27.7）。伊加和IgG抗体升高和低PG I与贲门癌无关。这些发现支持了H.幽门螺杆菌感染是非贲门部胃癌的一个原因。虽然H. pylori伊加、IgG抗体和低PG I可单独预测非贲门部胃癌的发生，其预测能力随分期和随访时间的长短而不同，联合应用时预测能力增强。(c)2006威利-利斯公司
The prediction of Helicobacter pylori antibodies immunoglobulin A (IgA) and immunoglobulin G (IgG) and serum pepsinogen I (PG 1) on gastric cancer occurrence was studied in a nested case-control study, based on 225 incident cancer cases and 435 matched controls from a Finnish cohort followed from 1966-1991. The odds ratio of noncardia gastric cancer between infected and noninfected persons was 3.12 (95% confidence interval (0) = 1.97-4.95) for elevated IgA and 2.88 (CI: 1.63-5.07) for elevated IgG antibodies. The odds ratio between low and high PG I was 2.24 (Cl: 1.43-3.49). The strength of association was significant for IgA antibodies during the total follow-up, but for IgG antibodies this was only true for follow-up periods of 15 years or more. IgA antibodies were significantly associated with all registered histological subtypes apart from intestinal type adenocarcinoma. The highest gastric cancer risk was found among individuals with simultaneously elevated IgA and IgG antibodies and low PG I with an odds ratio of 10.9 (Cl: 4.31-27.7) in comparison with those who were negative for both antibodies and had normal PIG I. Elevated IgA and IgG antibodies and low PG I were not associated with cancers of the gastric cardia. The findings support the hypothesis that H. pylori infection is a cause of noncardia gastric cancer. Although elevated H. pylori IgA and IgG antibodies and low PG I independently could predict the occurrence of noncardia gastric cancer, their power to do so varied with the stage and length of the follow-up period and it increased when they were applied in combination. (c) 2006 Wiley-Liss, Inc.