Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: A Case-Control Study.
Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: A Case-Control Study.
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DOI：
10.3928/23258160-20190503-05
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发表时间：
2019-05-01
期刊：
影响因子：
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通讯作者：
Maia, Mauricio
中科院分区：
文献类型：
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作者：
Melo, Gustavo Barreto;Figueira, Ana Carolina Migliorini;Maia, Mauricio
背景与目的：确定玻璃体内注射afliberceptinjection.Patients和方法后引起炎症的因素：本病例对照研究包括注射后炎症的aflibercept治疗眼和aflibercept治疗对照眼。分析病历以确定影响因素。进行生物物理测试以表征颗粒聚集的性质。结果：6只眼睛出现炎症，3名患者出现前葡萄膜炎，5名患者出现玻璃体细胞。所有病例均可见油滴。所有病例均使用萨尔达尼亚罗德里格斯（SR）注射器。在对照组中，SR和Becton-Dickinson注射器分别用于10只眼和17只眼。回归分析显示SR注射器与炎症之间存在相关性（比值比= 21.66; 95%置信区间，1.10-425.06; P = 0.043）。生物物理分析主要显示聚集可能从游离油滴或蛋白油滴aggregation.CONCLUSIONS：注射后炎症与SR注射器。硅油滴，尤其是在注射器搅动后，可能在炎症反应中发挥作用。[眼科手术激光成像视网膜。2019;50：288-294.]。
BACKGROUND AND OBJECTIVE: To determine factors causing inflammation after intravitreal aflibercept injections.PATIENTS AND METHODS: This case-control study included aflibercept-treated eyes with inflammation post-injection and aflibercept-treated control eyes. Medical records were analyzed to identify contributing factors. Biophysical tests were performed to characterize properties of particle aggregation. Institutional review board approval was obtained.RESULTS: Inflammation developed in six eyes; three patients had anterior uveitis, and five had vitreous cells. Oil droplets were seen in all cases. Saldanha Rodrigues (SR) syringes were used in all cases. Among controls, SR and Becton-Dickinson syringes were used in 10 and 17 eyes, respectively. Regression analysis showed an association between SR syringes and inflammation (odds ratio = 21.66; 95% confidence interval, 1.10-425.06; P = .043). Biophysical analyses primarily showed aggregation possibly from free oil droplets or protein-oil droplet aggregation.CONCLUSIONS: Post-injection inflammation was associated with SR syringes. Silicone oil droplets, especially after syringe agitation, might play a role in the inflammatory reaction. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:288-294.].