Mechanisms of Lymphatic Endothelial Cell Junction Transformations.
Mechanisms of Lymphatic Endothelial Cell Junction Transformations.
复制标题
淋巴内皮细胞连接转化的机制。
DOI：
10.1161/circresaha.123.323210
复制
发表时间：
2023
影响因子：
20.1
通讯作者：
Kon,Valentina
中科院分区：
文献类型：
--
作者：
Zhong,Jianyong;Shelton,ElaineL;Kirabo,Annet;Kon,Valentina
The lymphatic vascular network encompasses a series of blind-ended, unidirectional vessels that routes fluid, macromolecules, and cells from the interstitial compartments of virtually every organ for return into the systemic circulation. 1 Lymphatic vessels of the gut have specialized functions that include absorption of dietary lipids and fat-soluble vitamins, cholesterol transport, and gut immunosurveillance. This process begins with the uptake of interstitial fluid by the lymphatic capillaries, which coalesce and drain into collecting vessels equipped with valves that serve to propel lymph toward the thoracic duct and back into the systemic circulation. Lymphatic capillaries absorb interstitial fluid through discontinuous intercellular contacts between endothelial cells called button-like junctions while collecting vessels, lined by less-permeable zipper-like junctions facilitate the transport of lymph and prevent fluid backleak. 2 Although several studies have revealed junctional plasticity in initial lymphatics whereby button junctions transform into zippers or vice versa the mechanisms underlying these transformations are not well understood.
