THE PATIENTS DYING AFTER LONG TERMINAL PHASE HAVE ACIDOTIC BRAINS - IMPLICATIONS FOR BIOCHEMICAL MEASUREMENTS ON AUTOPSY TISSUE
THE PATIENTS DYING AFTER LONG TERMINAL PHASE HAVE ACIDOTIC BRAINS - IMPLICATIONS FOR BIOCHEMICAL MEASUREMENTS ON AUTOPSY TISSUE
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DOI：
10.1007/bf01251916
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
ERIKSSON, A
中科院分区：
文献类型：
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作者：
HARDY, JA;WESTER, P;ERIKSSON, A
尸检时测量额叶皮质和延髓的pH值显示，那些在长终末期后死亡的人的大脑pH值低于那些快速死亡的人。这些低pH值（pH 6.0-6.5）对应于已知具有神经毒性的乳酸浓度（20-25 mM）。脑脊液pH值和血液pH值与皮质pH值相关。这些观察结果的意义，死后人脑组织的生物化学和组织学研究及其可能的临床意义进行了讨论。
Measurement of the frontal cortex and the medullar oblongata pH at autopsy revealed that those brains from individuals who died after long terminal phase had lower pH than those who died quickly. These low pH (pH 6.0-6.5) corresponded to lactic acid concentrations (20-25 mM) which are known to be neurotoxic. The cerebrospinal fluid pH and blood pH correlated with the cortical pH. The significance of these observations to the study of the biochemistry and histology on post-mortem human brain tissue and their possible clinical relevance are discussed.