Activin A and follistatin in acute liver failure
Activin A and follistatin in acute liver failure
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DOI：
10.1097/00042737-200302000-00004
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发表时间：
2003-02-01
影响因子：
2.1
通讯作者：
Evans, LW
中科院分区：
文献类型：
--
作者：
Hughes, RD;Evans, LW
背景 在急性肝衰竭中，由于增殖反应的抑制或持续的肝细胞死亡，肝再生可能受到损害。激活素A是TGFβ超家族的成员，抑制肝细胞DNA合成并诱导细胞凋亡。方法采用酶联免疫吸附法测定23例急性肝衰竭患者血清中激活素A及其结合蛋白卵泡抑素的水平。结果与正常对照相比，急性肝衰竭患者血清激活素A显着升高（中位2.15ng/ml，范围0.28-6.87ng/ml） （中位数 0.25 ng/ml，范围 0.19-0.53 ng/ml；n = 10；P< 0.001）。然而，这与最终的疾病结果无关。与非甲型至戊型肝炎引起的急性肝衰竭患者（中位值 1.10 ng/ml，范围 0.28-2.70 ng/ml；n = 6；P< 0.05）。与正常对照相比，急性肝衰竭患者血清卵泡抑素也升高（中位值 2.84 ng/ml，范围 0.57-13.24 ng/ml）（中位值 0.68 ng/ml，范围 0.32-3.70 ng/ml；P < 0.01）。结论 血清激活素 A 在急性肝衰竭患者中升高，可能是抑制肝再生的一个因素。
Background Liver regeneration may be impaired in acute liver failure due to either inhibition of the proliferative response or ongoing liver cell death. Activin A, a member of the TGFbeta superfamily, inhibits hepatocyte DNA synthesis and induces apoptosis.Methods Levels of activin A and its binding protein follistatin in the serum of 23 patients with acute liver failure were determined by enzyme-linked immunosorbent assay.Results Serum activin A was significantly increased in acute liver failure patients (median 2.15 ng/ml, range 0.28-6.87 ng/ml) compared to normal controls (median 0.25 ng/ml, range 0.19-0.53 ng/ml; n = 10; P< 0.001). However, this was not linked to the final disease outcome. Higher levels of activin A were found in the serum of patients with acute liver failure due to paracetamol overdose (median 2.87 ng/ml, range 0.72-6.87 ng/ml; n = 17) than in patients with acute liver failure due to non-A to E hepatitis (median 1.10 ng/ml, range 0.28-2.70 ng/ml; n = 6; P< 0.05). Serum follistatin was also increased in acute liver failure patients (median 2.84 ng/ml, range 0.57-13.24 ng/ml) compared to normal controls (median 0.68 ng/ml, range 0.32-3.70 ng/ml; P < 0.01).Conclusion Serum activin A is increased in acute liver failure and could be a factor in the inhibition of liver regeneration.