The association of metabolic syndrome with left ventricular mass and geometry in community-based hypertensive patients among Han Chinese.
The association of metabolic syndrome with left ventricular mass and geometry in community-based hypertensive patients among Han Chinese.
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中国汉族社区高血压患者代谢综合征与左心室质量和几何形状的关系
DOI：
10.4103/1735-1995.172785
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Hui R
中科院分区：
文献类型：
--
作者：
Wang S;Song K;Guo X;Xue H;Wang N;Chen J;Zou Y;Sun K;Wang H;He J;Hui R
背景：代谢综合征（MS）与左心室（LV）肥厚的关系存在争议。本研究的目的是探讨MS对社区汉族高血压患者左室质量和几何结构的影响。材料与方法：这项研究包括1733名根据国际糖尿病联盟（IDF）定义的代谢综合征患者和2373名非MS高血压患者。根据LV质量≥49.2 g/m2.7（男性）和46.7 g/m2.7（女性）的标准诊断LV肥大。根据左室肥厚和相对室壁厚度计算左室几何构型（正常、向心性重构、向心性或离心性肥厚）。采用Logistic回归分析确定MS与左室肥厚和左室几何结构异常的比值比（OR）和95%置信区间（CI）。结果：MS组左室质量和左室质量指数均高于非MS组。在多个调整模型中。随着MS疾病数量的增加，LV质量指数、LV质量、室间隔和后壁均升高。MS与LV肥大风险增加（未校正OR 1.38; 95% CI 1.21-1.57）;年龄、性别和血压（BP;校正OR 1.39; 95% CI 1.22-1.59）相关。MS还与男性和女性患者离心性肥大的风险增加相关。MS仅与女性患者的向心性肥大风险增加相关; MS与向心性重塑无关。结论：LV质量和LV质量指数与中国社区高血压人群中MS疾病数量增加相关。MS不仅与左室肥厚风险增加相关，而且与左室几何构型的向心性和偏心性异常相关，尤其是在女性中。
Background: The association of metabolic syndrome (MS) with left ventricular (LV) hypertrophy is controversial. The objective of our study was to investigate the influence of MS on LV mass and geometry in community-based hypertensive patients among Han Chinese. Materials and Methods: This study included 1733 metabolic syndrome patients according to the International Diabetes Federation (IDF) definition and 2373 non-MS hypertension patients. LV hypertrophy was diagnosed by the criteria of LV mass ≥49.2 g/m2.7 for men and 46.7 g/m2.7 for women. LV geometric patterns (normal, concentric remodeling, concentric or eccentric hypertrophy) were calculated according to LV hypertrophy and relative wall thickness. Logistic regression analysis was used to determine odds ratio (OR) and 95% confidence interval (CI) of MS for LV hypertrophy and LV geometry abnormality. Results: The LV mass and LV mass index were higher in the MS group than in the non-MS group. In multiple adjusted models. LV mass index, LV mass, interventricular septum, and post wall were raised with the increased number of MS disorders. MS was associated with increased LV hypertrophy risk (unadjusted OR 1.38; 95% CI 1.21-1.57); age, sex, and blood pressure (BP; adjusted OR 1.39; 95% CI 1.22-1.59). MS was also associated with increased risk of eccentric hypertrophy in male and female patients. MS was only associated with increased risk of concentric hypertrophy in female patients; and MS was not associated with concentric remodeling. Conclusion: LV mass and LV mass index were associated with the increased number of MS disorders in the Chinese community-based hypertensive population. MS was not only associated with increased LV hypertrophy risk, but also associated with concentric and eccentric LV geometry abnormality, especially in females.