iBone: A Reaction Diffusion Based Shape Optimization Method
iBone: A Reaction Diffusion Based Shape Optimization Method
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iBone：基于反应扩散的形状优化方法
DOI：
10.4028/www.scientific.net/kem.243-244.601
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Kikuchi
中科院分区：
文献类型：
--
作者：
Ken;Y. Wada;M. Kikuchi
骨是一种高度专业化的结缔组织，由有机和无机材料组成。骨通过骨形成成骨细胞和吸收骨破细胞不断重塑。在陆生脊椎动物中，这两种活动是严格平衡的，并且通过从食物中摄入有限的钙来使骨骼形状适应局部压力。然而，该系统背后基于细胞的适应机制尚未得到充分考虑。最近，我们发现人类间充质干细胞受到成骨细胞谱系的强烈刺激，形成类似于反应扩散模型中观察到的图灵模式的凝聚模式。我们基于局部应力加权的反应扩散模型，通过耦合骨形成和骨吸收活动，构建了骨重塑的假设模型（iBone）。当外部机械应力施加到样本模型时，刺激的骨形成和随后的骨吸收激活有效地使其形状适应给定的应力，并产生平坦的应力分布。 iB 还可以修复导致应力分布不均匀的骨折。 i Bone 的功效提出了一个主要模型，即骨细胞如何形成一个协作系统，使骨的微观结构适应自愿的机械负荷；并且，表明基于单元的并行计算系统，例如反应扩散系统，可以用于设计有效的应力适应模型。
Bone is a highly specialized form of connective tissue consisting of org anic and inorganic materials. Bone is continuously remodeled by bone forming osteoblasts and resorbing ost eoclast . In terrestrial vertebrates, these two activities are strictl y ba anced and adapt the shape of bone to the local stress with limited calcium intake from foods. However, the cell based-adaptation mechanism underlying this system have not been well considered. Recently, we have found that human mesenchymal stem cells strongly stimulated towards osteoblasti c lineage form a condensation pattern similar to Turing patterns observed in reaction-diffusion models. We c onstructed a hypothetical model of bone remodeling (iBone), by coupling the bone forming and resorbing ac t vities based on the reaction-diffusion model weighed by local stress. When an externa l mechanical stress was applied to a sample model, stimulated bone formation and subsequent activation of bone resorption efficiently adapted the shape of it to the given stress, and created flat stress distribution. iB one could also repair fractures which caused uneven stress distribution. The efficacy of i Bone proposes a principal model how bone cells can form a cooperative system that adapt the microst ru ture of bone to the voluntary mechanical loads; and, suggests that element based-parallel computi ng system, such as reaction-diffusion system, can be applied for designing efficient stress adapta tion models.