Polythosides A and B, two new triterpenoid saponins from the roots of Acacia polyacantha Willd. (Mimosaceae)
Polythosides A and B, two new triterpenoid saponins from the roots of Acacia polyacantha Willd. (Mimosaceae)
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Polythosides A 和 B，是来自 Acacia polyacantha Willd 根部的两种新三萜皂苷。
DOI：
10.1016/j.phytol.2021.04.007
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发表时间：
2021
影响因子：
1.7
通讯作者：
Shiono Yoshihito
中科院分区：
文献类型：
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作者：
Tchoukoua Abdou;Tomfeun Nganou Sandrine Carole;Dabole Bernard;Yoshida Jun;Ito Yoshiaki;Ngadjui Bonaventure Tchaleu;Shiono Yoshihito
从多刺金合欢（Acaciapolyacantha）的根中分得两个新的齐墩果烷型三萜皂苷，分别命名为polythosides A和B（1和2），以及一个已知化合物silphioside E（3）。通过1D和2D-NMR实验和质谱分析鉴定了它们的结构（HR-ESITOF-MS）为油酸3-O-β-d-吡喃半乳糖基-（1→2）-β-d-吡喃木糖基-（1→6）-[β-d-吡喃木糖基-（1→4）]-[β-d-吡喃木糖基-（1→2）]-β-d-吡喃半乳糖苷（1），3-O-[β-d-吡喃半乳糖基-（1→2）-β-d-吡喃木糖基-（1→6）-[β-d-吡喃木糖基-（1→4）]-[β-d-吡喃木糖基-（1→2）]-β-d-吡喃半乳糖基]油酸-28-O-β-d-吡喃葡萄糖基酯（2）和3-O-β-d-吡喃葡萄糖基-（1→2）-β-d-吡喃葡萄糖基]油酸28-O-β-d-吡喃葡萄糖酯（3）。在H4 IIE大鼠肝癌细胞系上评价分离的皂苷的细胞毒性作用。结果表明，所有化合物（在100 μM下测定）均未显示出对H4 IIE细胞的细胞毒性。
Two new oleanane-type triterpene saponins, named polythosides A and B (1and2), together with a known compound, silphioside E (3), were isolated from the roots ofAcaciapolyacantha. Their structures were elucidated by analysis of 1D and 2D-NMR experiments, and mass spectrometry (HR-ESITOF-MS) as oleanolic acid 3-O-β-d-galactopyranosyl-(1→2)-β-d-xylopyranosyl-(1→6)-[β-d-xylopyranosyl-(1→4)]-[β-d-xylopyranosyl-(1→2)]-β-d-galactopyranoside (1), 3-O-[β-d-galactopyranosyl-(1→2)-β-d-xylopyranosyl-(1→6)-[β-d-xylopyranosyl-(1→4)]-[β-d-xylopyranosyl-(1→2)]-β-d-galactopyranosyl] oleanolic acid-28-O-β-d-glucopyranosyl ester (2) and 3-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl] oleanolic acid 28-O-β-d-glucopyranosyl ester (3). The cytotoxic effect of isolated saponins was evaluated on the H4IIE rat hepatoma cell line. The results show that none of the compounds (assayed at 100 μM) showed cytotoxicity against H4IIE cells.