Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex reduces resting-state insula activity and modulates functional connectivity of the orbitofrontal cortex in cigarette smokers.
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex reduces resting-state insula activity and modulates functional connectivity of the orbitofrontal cortex in cigarette smokers.
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DOI：
10.1016/j.drugalcdep.2017.02.002
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发表时间：
2017-05-01
影响因子：
4.2
通讯作者：
George MS
中科院分区：
文献类型：
--
作者：
Li X;Du L;Sahlem GL;Badran BW;Henderson S;George MS
以前的研究报道，重复的经颅磁刺激(RTMS)可以减少吸烟者对线索的渴望，减少吸烟的消费。然而，这种效应的机制尚不清楚。我们使用静息功能磁共振成像(RsfMRI)来测试rTMS在非寻求治疗的吸烟者中的效果。我们使用了单盲、假对照、随机平衡交叉设计，参与者经历了两次访问，间隔至少一周。参与者在其中一次访问中接受了左侧背外侧前额叶皮质(DLPFC)的主动rTMS，在另一次访问中接受了假rTMS。他们在每次rTMS会话前后进行了两次rsFMRI扫描。我们使用与先前研究相同的rTMS刺激参数(10赫兹，5秒开启，10秒关闭，100%静息运动阈值，3000次脉冲)。10名不寻求治疗、依赖尼古丁的吸烟者(6名女性，平均年龄39.72岁，平均每天吸烟17.30支)完成了这项研究。RsFMRI结果表明，与单次假rTMS相比，单次rTMS活动以低频波动幅度分数(FALFF)的形式抑制右侧脑岛和丘脑的脑活动。对于固有的大脑连接性比较，活跃的TMS导致从rTMS部位到左侧眶内侧前额皮质的连接性显著降低。这一数据表明，根据fALFF的测量，一次rTMS可以减少右侧脑岛和右侧丘脑的活动。数据还表明，rTMS可以降低左侧DLPFC和内侧眶前皮质之间的rsFC。
Previous studies reported that repetitive transcranial magnetic stimulation (rTMS) can reduce cue-elicited craving and decrease cigarette consumption in smokers. The mechanism of this effect however, remains unclear. We used resting-state functional magnetic resonance imaging (rsfMRI) to test the effect of rTMS in non-treatment seeking smokers. We used a single blinded, sham-controlled, randomized counterbalanced crossover design where participants underwent two visits separated by at least 1 week. Participants received active rTMS over the left dorsolateral prefrontal cortex (DLPFC) during one of their visits, and sham rTMS during their other visit. They had two rsFMRI scans before and after each rTMS session. We used the same rTMS stimulation parameters as in a previous study (10 Hz, 5 seconds-on, 10 seconds-off, 100% resting motor threshold, 3000 pulses). Ten non-treatment-seeking, nicotine-dependent, cigarette smokers (6 women, an average age of 39.72 and an average cigarette per day of 17.30) finished the study. rsFMRI results demonstrate that as compared to a single session of sham rTMS, a single session of active rTMS inhibits brain activity in the right insula and thalamus in fractional amplitude of low frequency fluctuation (fALFF). For intrinsic brain connectivity comparisons, active TMS resulted in significantly decreased connectivity from the site of rTMS to the left orbitomedial prefrontal cortex. This data suggests that one session of rTMS can reduce activity in the right insula and right thalamus as measured by fALFF. The data also demonstrates that rTMS can reduce rsFC between the left DLPFC and the medial orbitofrontal cortex.