Semiautomatic brain region extraction: a method of parcellating brain regions from structural magnetic resonance images
Semiautomatic brain region extraction: a method of parcellating brain regions from structural magnetic resonance images
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DOI：
10.1016/j.neuroimage.2004.03.023
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发表时间：
2004-08-01
期刊：
影响因子：
5.7
通讯作者：
Black, SE
中科院分区：
文献类型：
--
作者：
Dade, LA;Gao, FQ;Black, SE
结构磁共振成像已成为必不可少的区域脑变化的评估在健康老龄化和疾病相关的过程。已经开发了几种方法来测量结构尺寸和局部脑体积，但是这些方法中的许多方法涉及大量的手动追踪和/或界标识别。我们提出了一种新的技术，半自动脑区域提取（SABRE），为快速和可靠的皮层和皮层下的大脑区域的分割。我们将SABRE分组与组织隔室分割[NeuroImage 17（2002）1087]相结合，以产生26个脑区域的灰质（GM）、白色（WM）、脑室CSF和脑沟CSF的测量值。由于SABRE将用户输入限制在少数容易识别的标志，因此所有体积的评分者间可靠性都很高，所有系数都在0.91和0.99之间。为了评估结构效度，我们对比了健康年轻人和老年人的SABRE-derived体积数据。SABRE包裹和组织分割的结果显示，多个脑区域存在显著差异，与研究人员使用冗长的手动追踪方法在文献中描述的区域萎缩一致。我们的研究结果表明，SABRE是一种可靠的半自动方法，用于评估区域组织体积，提供了显着的节省时间的纯手动方法，但保留有关个人的皮质地标的信息。(C)2004年爱思唯尔公司All rights reserved.
Structural MR imaging has become essential to the evaluation of regional brain changes in both healthy aging and disease-related processes. Several methods have been developed to measure structure size and regional brain volumes, but many of these methods involve substantial manual tracing and/or landmark identification. We present a new technique, semiautomatic brain region extraction (SABRE), for the rapid and reliable parcellation of cortical and subcortical brain regions. We combine the SABRE parcellation with tissue compartment segmentation [NeuroImage 17 (2002) 1087] to produce measures of gray matter (GM), white matter (WM), ventricular CSF, and sulcal CSF for 26 brain regions. Because SABRE restricts user input to a few easily identified landmarks, inter-rater reliability is high for all volumes, with all coefficients between 0.91 and 0.99. To assess construct validity, we contrasted SABRE-derived volumetric data from healthy young and older adults. Results from the SABRE parcellation and tissue segmentation showed significant differences in multiple brain regions in keeping with regional atrophy described in the literature by researchers using lengthy manual tracing methods. Our findings show that SABRE is a reliable semiautomatic method for assessing regional tissue volumes that provides significant timesavings over purely manual methods, yet maintains information about individual cortical landmarks. (C) 2004 Elsevier Inc. All rights reserved.