Nitric oxide synthesis from L-arginine modulates renal vascular resistance in isolated perfused and intact rat kidneys
Nitric oxide synthesis from L-arginine modulates renal vascular resistance in isolated perfused and intact rat kidneys
复制标题
L-精氨酸合成一氧化氮调节离体灌注和完整大鼠肾脏的肾血管阻力
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
R. Levi
中科院分区：
文献类型：
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作者：
W. Welch;C. Wilcox;K. Aisaka;S. Gross;O. Griffith;B. Fontoura;T. Maack;R. Levi
本研究使用完整和离体灌注大鼠肾脏，测试了N G -甲基- l-精氨酸（L-NMMA）阻断l-精氨酸合成一氧化氮（NO）对肾脏血流动力学的影响。麻醉大鼠输注L-NMMA，仅在肾灌注压力维持在控制水平时，平均动脉压升高，肾小球滤过率和肾血浆流量降低。在离体肾脏中，L-NMA增加血管阻力；这是由l -精氨酸共同管理减弱。
This study tested the effects on renal hemodynamics of blockage of nitric oxide (NO) synthesis from L-arginine with N G -methyl-L-arginine (L-NMMA) using both intact and isolated perfused rat kidneys. Infusion of L-NMMA into anesthetized rats increased the mean arterial pressure and reduced the glomerular filtration rate and renal plasma flow only when the renal perfucion pressure was maintained at control levels. In isolated kidneys, L-NMA increased vascular resistance; this was attenuated by coadministration of L-arginine.