Genetic studies of bipolar affective disorder in large families
Genetic studies of bipolar affective disorder in large families
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DOI：
10.1192/bjp.178.41.s134
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发表时间：
2001-06-01
影响因子：
10.5
通讯作者：
Muir, WJ
中科院分区：
文献类型：
--
作者：
Blackwood, DHR;Visscher, PM;Muir, WJ
背景遗传因素在双相情感障碍的病因学中是重要的。目的回顾双相情感障碍多发病大家族的连锁研究。方法选择性回顾双相情感障碍连锁研究，强调研究多发病大家族的优点和缺点，并比较用于数据分析的统计方法。结果双相情感障碍与几个染色体区域的连锁，包括4p，4q，10p、12q、16p、18q、21q和Xq在大家庭中首次报道。在其他家族中，与情感疾病相关的染色体重排为疾病相关基因的定位提供了路标。使用方差分量方法的统计分析可以适用于大家庭，不需要事先了解疾病的遗传，并可以测试多位点models.Conclusion研究单一的大家系结合方差分量分析是一种高效和有效的策略，可能会导致进一步深入了解双相情感障碍的遗传基础。
Background Genetic factors are known to be important in the aetiology of bipolar disorder.Aims To review linkage studies in extended families multiply affected with bipolar disorder.Method Selective review of linkage studies of bipolar disorder emphasising the gains and drawbacks of studying large multiply-affected families and comparing the statistical methods used for data analysis.Results Linkage of bipolar disorder to several chromosome regions including 4p, 4q, 10p, 12q, 16p, 18q, 21q and Xq has first been reported in extended families. In other families chromosomal rearrangements associated with affective illnesses provide signposts to the location of disease-related genes. Statistical analyses using variance component methods can be applied to extended families, require no prior knowledge of the disease inheritance, and can test multilocus models.Conclusion Studying single large pedigrees combined with variance component analysis is an efficient and effective strategy likely to lead to further insights into the genetic basis of bipolar disorders.