Investigation of photodynamic effect caused by MPPa-PDT on breast cancer
Investigation of photodynamic effect caused by MPPa-PDT on breast cancer
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DOI：
10.7452/lapl.201210077
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发表时间：
2012-08
影响因子：
1.7
通讯作者：
Y. Tian;X. Hu;W. Leung;H. Yuan;L. Zhang;F. Cui;X. Tian
中科院分区：
文献类型：
--
作者：
Y. Tian;X. Hu;W. Leung;H. Yuan;L. Zhang;F. Cui;X. Tian
乳腺癌是常见的恶性肿瘤，发病率随着年龄的增长而增加。光动力疗法(PDT)是一种应用于肿瘤的新技术，它包括给肿瘤局部使用光敏剂，然后激活特定的波长。脱镁叶绿酸-a甲酯(MPPA)是一种新型的高效光敏剂，是一种新型的叶绿素衍生物。我们正在探索MPPA-PDT对乳腺癌的光动力学效应。体内外实验表明，MPPA是一种较为理想的光敏剂，可诱导乳腺癌细胞凋亡。
Breast cancer is the common malignant tumor, the incidence increases with age. Photodynamic therapy (PDT) is a new technique applied in tumors, which involves the administration of a tumor localizing photosensitizer and it is followed by the activation of a specific wavelength. Pyropheophorbide-a methyl ester (MPPa), a derivative of chlorophyll, is a novel potent photosensitizer. We are exploring the photodynamic effect caused by MPPa-PDT on breast cancer. The in vitro and in vivo experiments indicate that MPPa is a comparatively ideal photosensitizer which can induce apoptosis in breast cancer.