Monosynaptic excitation of dorsal medullary respiratory neurons by slowly adapting pulmonary stretch receptors.
Monosynaptic excitation of dorsal medullary respiratory neurons by slowly adapting pulmonary stretch receptors.
复制标题
通过缓慢适应肺牵张感受器来单突触激发背髓呼吸神经元。
DOI：
10.1152/jn.1984.52.4.771
复制
发表时间：
1984
影响因子：
2.5
通讯作者：
Berger,AJ
中科院分区：
文献类型：
--
作者：
Averill,DB;Cameron,WE;Berger,AJ
在麻醉、麻痹、人工通气的猫上，同时记录了孤束腹外侧亚核内单个肺牵张感受器（PSR）和背侧呼吸组（DRG）单个呼吸神经元的放电。DRG神经元被分类为P-细胞，I-α，或I-β，基于呼吸周期期间的活动变化，当肺膨胀被抑制时，与肺膨胀时的活动相比，与中枢吸气驱动相一致。在某些情况下，迷走神经刺激也被用来分类呼吸神经元。通过构建同时记录的单个PSR（参考事件）和单个DRG神经元（相关事件）放电的交叉相关图，检查PSR到DRG神经元的突触输入。单突触兴奋性连接被证明在26%的PSR和P-细胞对的交叉相关图和20%的PSR和I-β神经元对的交叉相关图的峰值。P细胞和I-β神经元的峰值发生次数与背景发生次数（k值）的比值相当：分别为2.96 +/- 2.09和1.62 +/- 0.36（平均值+/- SD）。P-细胞和I-β神经元也具有相似的放电概率增加峰值的短时间：分别为2.74 +/- 0.53和2.57 +/- 0.63 ms。没有证据表明PSR和I-α神经元之间存在突触连接。这种负面的结果的解释进行了讨论。
The discharges of individual slowly adapting pulmonary stretch receptors (PSRs) and single respiratory neurons of the dorsal respiratory group (DRG) within the ventrolateral subnucleus of the solitary tract were recorded simultaneously in anesthetized, paralyzed, artificially ventilated cats. DRG neurons were classified as P-cell, I-alpha, or I-beta, based on the alteration in activity during respiratory cycles when lung inflation was withheld compared to activity when the lungs were inflated in phase with central inspiratory drive. In some cases, vagal stimulation was also used to classify respiratory neurons. Synaptic input of PSRs onto DRG neurons was examined by the construction of cross-correlograms for the simultaneously recorded discharge of individual PSRs (reference events) and individual DRG neurons (correlated events). Monosynaptic excitatory connections were demonstrated by peaks in 26% of the cross-correlograms of PSR and P-cell pairs and 20% of the cross-correlograms of PSR and I-beta neuron pairs. The ratio of the peak number of occurrences to the background number of occurrences (k value) was comparable for P-cells and I-beta neurons: 2.96 +/- 2.09 and 1.62 +/- 0.36 (mean +/- SD), respectively. P-cells and I-beta neurons also had similar short latencies for the peak of increased probability of discharge: 2.74 +/- 0.53 and 2.57 +/- 0.63 ms, respectively. No evidence was obtained demonstrating synaptic connectivity between PSRs and I-alpha neurons. Interpretations of this negative result are discussed.