Methionine sulfoximine prevents the accumulation of large neutral amino acids in brain of hyperammonemic rats.
Methionine sulfoximine prevents the accumulation of large neutral amino acids in brain of hyperammonemic rats.
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蛋氨酸亚磺酰亚胺可防止高氨血症大鼠脑中大量中性氨基酸的积累。
DOI：
10.1016/0022-4804(84)90110-0
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
J. Fischer
中科院分区：
文献类型：
--
作者：
T. Jonung;P. Rigotti;B. Jeppsson;J. James;J. C. Peters;J. Fischer
中性氨基酸通过血脑屏障的转运改变而在脑中蓄积似乎是门体分流和高氨血症的结果。有研究表明，脑内高浓度的谷氨酰胺（脑氨解毒的产物）加速了其他中性氨基酸从血液向脑的转运。为了验证这一假设，正常大鼠输注铵盐与或不预处理与l-蛋氨酸-dl-亚砜亚胺（MSO），谷氨酰胺合成的抑制剂。MSO预处理可以阻止大多数铵盐诱导的脑中性氨基酸浓度变化，这表明高氨血症通过导致脑谷氨酰胺水平升高来改变中性氨基酸穿过血脑屏障的转运。
Accumulation of neutral amino acids in the brain due to altered transport across the blood-brain barrier appears to be a consequence of portal-systemic shunting and hyperammonemia. It has been suggested that high brain concentrations of glutamine, a product of cerebral ammonia detoxification, accelerates the transport of other neutral amino acids from blood to brain. To test this hypothesis, normal rats were infused with ammonium salts with or without pretreatment withl-methionine-dl-sulfoximine (MSO), an inhibitor of glutamine synthesis. Pretreatment with MSO prevented most ammonium salt-induced changes in the concentrations of the neutral amino acids in brain, suggesting that hyperammonemia alters the transport of neutral amino acids across the blood-brain barrier by causing the brain glutamine level to rise.