Role of the 5-HT1A Autoreceptor in the Enhancement of Fluvoxamine-Induced Increases in Prefrontal Dopamine Release by Adrenalectomy/Castration in Mice.
Role of the 5-HT1A Autoreceptor in the Enhancement of Fluvoxamine-Induced Increases in Prefrontal Dopamine Release by Adrenalectomy/Castration in Mice.
复制标题
5-HT1A 自身受体在增强氟伏沙明诱导的小鼠肾上腺切除/去势前额多巴胺释放增加中的作用。
DOI：
10.1016/j.jphs.2015.01.001
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发表时间：
2014
影响因子：
3.5
通讯作者：
Matsuda T
中科院分区：
文献类型：
--
作者：
Hasebe S;Hiramatsu N;Ago Y;Mori K;Watabe Y;Hashimoto H;Takuma K;Matsuda T
我们已经发现，氟伏沙明诱导的前额叶多巴胺释放增加增强肾上腺切除术/去势和5-HT 1A受体参与增强。本研究探讨了哪些5-HT 1A自身受体或突触后受体在小鼠的增强中起关键作用。局部灌注5-HT 1A受体拮抗剂WAY 100635（10 μM）不能阻断肾上腺切除/去势诱导的氟伏沙明诱导的多巴胺释放增加的增强，而全身给予低剂量（0.1 mg/kg）WAY 100635（优先阻断自身受体介导的反应）可阻断该增强。提示5-HT_（1A）自身受体在促进前额叶多巴胺释放中起重要作用。
We have found that fluvoxamine-induced increases in prefrontal dopamine release are enhanced by adrenalectomy/castration and 5-HT1Areceptors are involved in the enhancement. This study examined which 5-HT1Aautoreceptors or postsynaptic receptor play a key role in the enhancement in mice. Adrenalectomy/castration-induced enhancement of fluvoxamine-induced increase in the dopamine release was not blocked by local perfusion with the 5-HT1Areceptor antagonist WAY100635 (10 μM), while it was blocked by systemic administration of WAY100635 at low dose (0.1 mg/kg) which blocked preferentially autoreceptor-mediated responses. These finding suggests that 5-HT1Aautoreceptors play a key role in the enhancement of prefrontal dopamine release.