Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues
Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues
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DOI：
10.1007/s12032-013-0670-0
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发表时间：
2013-09-01
期刊：
影响因子：
3.4
通讯作者：
Zeinoddini, Mehdi
中科院分区：
文献类型：
--
作者：
Hajjari, Mohammadreza;Behmanesh, Mehrdad;Zeinoddini, Mehdi
HOTAIR是一种已知的长非编码RNA，最近与某些癌症类型的进展有关。据报道，HOTAIR表达与SUZ12表达水平相关，因此可能影响癌组织的表观遗传状态。在此，我们发现HOTAIR在胃腺癌组织中的表达与正常的邻近胃上皮组织相比异常上调。HOTAIR的异常表达与胃癌的TNM分期和淋巴结转移有关。因此，推测HOTAIR和SUZ12基因在胃腺癌组织中可能存在协同表达。该结果表明HOTAIR长非编码RNA在胃癌进展中的作用。
HOTAIR is a known long non-coding RNA which has recently been associated with the progression of some cancer types. It has been reported that HOTAIR expression is correlated with SUZ12 expression level and therefore may affect the epigenetic state of cancer tissues. Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR and SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long non-coding RNA in gastric cancer progression.