Familial occurrence of Kawasaki syndrome in North America
Familial occurrence of Kawasaki syndrome in North America
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DOI：
10.1001/archpedi.159.9.876
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Burns, JC
中科院分区：
文献类型：
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作者：
Dergun, M;Kao, A;Burns, JC
目的：描述多个成员的家庭与川崎综合征（KS），以提高认识的家庭发生的KS从业者谁照顾这些patients.Design：回顾性审查的医疗记录在2个医疗中心和数据收集从远程KS家庭谁联系的KS研究计划在加州大学，圣地亚哥。结果：18个家庭与多个受影响的成员被确定。有9个家庭有2个受影响的兄弟姐妹。在圣地亚哥，424个KS家庭中有3个（0.7%）有兄弟姐妹病例。9个家庭被确定与KS在2代或多个受影响的成员，产生共24 KS受影响的儿童。没有明确的遗传模式，可以推断出这些家系，很可能是多个多态性等位基因影响KS susceptibility.Conclusion：医生应咨询受影响的家庭，使他们意识到潜在的风险增加KS的家庭成员。
Objective: To describe families with multiple members affected with Kawasaki syndrome (KS) to increase awareness of the familial occurrence of KS among practitioners who care for these patients.Design: Retrospective review of medical records at 2 medical centers and data collection from remote KS families who contacted the KS Research Program at the University of California, San Diego.Results: Eighteen families with multiple affected members were identified. There were 9 families with 2 affected siblings. In San Diego, 3 (0.7%) of 424 KS families had sibling cases. Nine families were identified with KS in 2 generations or in multiple affected members, yielding a total of 24 KS-affected children. No clear pattern of inheritance could be deduced from these pedigrees, and it is likely that multiple polymorphic alleles influence KS susceptibility.Conclusion: Physicians should counsel affected families and make them aware of the potential increased risk of KS among family members.