Incidence and mortality of primary sclerosing cholangitis in the UK: A population-based cohort study
Incidence and mortality of primary sclerosing cholangitis in the UK: A population-based cohort study
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DOI：
10.1016/j.jhep.2008.02.017
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发表时间：
2008-06-01
影响因子：
25.7
通讯作者：
West, Joe
中科院分区：
文献类型：
--
作者：
Card, Tim R.;Solaymani-Dodaran, Masoud;West, Joe
背景/目标：关于英国人群中原发性硬化性胆管炎（PSC）的发生率及其相关的死亡率和恶性肿瘤风险知之甚少。我们的目的是填补这些空白的knowledge.Methods：我们确定了223人与PSC和2217控制科目的全科医学研究数据库在英国。我们计算了（1991-2001年）和死亡率，并使用泊松和考克斯回归进行人口之间的比较。有149起事故，发生率为每10万人年0.41起（95% CI 0.34-0.48），2001年的患病率为3.85/100，000（95% CI 3.04 - 4.80）。在研究期间，PSC的发病率增加了约50%，男性高于女性。死亡率增加了三倍（与一般人群相比，PSC患者的风险比为2.92（95% CI 2.16-3.94），任何恶性肿瘤的风险增加2倍，原发性肝癌的风险增加40倍。（HR分别为2.23和37.44）。我们相信这篇论文提供了英国现有的PSC发生率及其死亡和恶性肿瘤风险的最可靠估计。迄今(c)2008年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: Little is known about the occurrence of Primary Sclerosing Cholangitis (PSC) in the population of the United Kingdom or its associated risks of mortality and malignancy. We aimed to fill these gaps in knowledge.Methods: We identified 223 people with PSC and 2217 control subjects from the General Practice Research Database in the UK. We calculated incidence rates (1991-2001) and mortality rates and used Poisson and Cox regression to make comparisons between populations.Results: There were 149 incident cases giving a rate of 0.41 per 100,000 person years (95% CI 0.34-0.48) and a prevalence in 2001 of 3.85 per 100,000 (95% CI 3.04 to 4.80). The incidence of PSC increased about 50%, over the period studied and was higher in men compared with women. There was a three-fold mortality rate increase (Hazard ratio 2.92 (95% CI 2.16-3.94) in people with PSC compared to the general population, a two-fold increase in risk of any malignancy and a 40-fold increase in the risk of primary liver cancer (HR 2.23 and 37.44, respectively).Conclusions: We believe this paper provides the most reliable estimates of the occurrence of PSC and of its risk in terms of death and malignancy in the UK available to date. (c) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.