ASSOCIATIONS OF LIPOPROTEIN CHOLESTEROLS, APOLIPOPROTEIN-A-I AND APOLIPOPROTEIN-B, AND TRIGLYCERIDES WITH CAROTID ATHEROSCLEROSIS AND CORONARY HEART-DISEASE - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
ASSOCIATIONS OF LIPOPROTEIN CHOLESTEROLS, APOLIPOPROTEIN-A-I AND APOLIPOPROTEIN-B, AND TRIGLYCERIDES WITH CAROTID ATHEROSCLEROSIS AND CORONARY HEART-DISEASE - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
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DOI：
10.1161/01.atv.14.7.1098
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发表时间：
1994-07-01
期刊：
影响因子：
--
通讯作者：
DAVIS, CE
中科院分区：
文献类型：
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作者：
SHARRETT, AR;PATSCH, W;DAVIS, CE
以往的研究表明，与对照组相比，冠心病（CHD）患者的载脂蛋白B（apo B）水平升高的比例通常大于低密度脂蛋白胆固醇（LDL-C）。社区动脉粥样硬化风险研究提供了7261名无心血管症状的男性和女性的一般人群，用于评价超声成像测量的颅外颈动脉内膜-中层增厚与空腹血浆LDL-C、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白B、载脂蛋白A-I（apoA-I）、甘油三酯和HDL密度亚组分之间的相关性。选择CHD组进行比较。血脂因子与颈动脉厚度呈近似线性相关：LDL-C和血浆apoB阳性，HDL-C和apoA-I水平阴性。在考虑LDL-C和HDL-C后，载脂蛋白和HDL密度亚组分对相关性没有贡献。与对照组相比，颈动脉厚度超过0.9 mm的人LDL-C升高的比例大于apoB，而HDL-C降低的比例较小。CHD病例受试者的apoB升高比例大于LDL-C。尽管与无症状颈动脉壁增厚和狭窄性冠状动脉疾病相关的血脂谱相似，但发现的差异表明LDL-C是动脉粥样硬化形成早期最重要的脂质因子，而富含甘油三酯的脂蛋白的代谢及其对LDL和HDL的影响可能与晚期动脉粥样硬化血栓形成过程更相关。
Previous research shows generally greater proportional elevation in apolipoprotein B (apoB) levels than in low-density lipoprotein cholesterol (LDL-C) in coronary heart disease (CHD) case subjects compared with control subjects. The Atherosclerosis Risk in Communities study provided general populations of 7261 men and women free of cardiovascular symptoms for evaluating the associations between intima-media thickening in extracranial carotid arteries measured using ultrasound imaging and fasting plasma LDL-C, high-density lipoprotein cholesterol (HDL-C), apoB, apolipoprotein A-I (apoA-I), triglycerides, and HDL density subfractions. A CHD group was selected for comparison. Lipid factors show approximately linear associations with carotid thickness: positive for LDL-C and plasma apoB and negative for HDL-C and apoA-I levels. Apolipoproteins and HDL density subfractions did not contribute to the association after accounting for LDL-C and HDL-C. Compared with control subjects, persons whose carotid thickness exceeded 0.9 mm had greater proportional elevations in LDL-C than in apoB, whereas HDL-C reductions were small. CHD case subjects showed greater proportional elevations of apoB than LDL-C. Although the lipid profiles associated with asymptomatic carotid wall thickening and stenotic coronary disease are similar, the differences found suggest that LDL-C is the most important lipid factor in earlier stages of atherogenesis, whereas the metabolism of triglyceride-rich lipoproteins and its effects on LDL and HDL may be more relevant to later atherothrombotic processes.