Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases
Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases
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DOI：
10.1080/22221751.2019.1701954
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发表时间：
2020-01-01
影响因子：
13.2
通讯作者：
Giovanetti, Marta
中科院分区：
文献类型：
--
作者：
Pereira Gusmao Maia, Zuinara;Mota Pereira, Felicidade;Giovanetti, Marta
在2017年6月至2018年8月期间，位于巴伊亚州（巴西）的几个城市报告说，出现类似于虫媒病毒感染的发热性疾病的患者数量大幅增加。使用便携式全基因组测序、分子钟和流行病学分析的组合，我们揭示了CHIKV-ECSA基因型返回到巴伊亚。我们的研究结果表明，在一些城市的血统和重新引入新的流行病学菌株从不同的巴西地区，强调了一个复杂的动态之间的传播流行季节和采样地点的本地持久性。CHIKV的估计气候驱动传播潜力多年来保持在类似水平，因此确诊病例总数的大幅减少表明，自2014年引入以来，在巴伊亚流行的4年中，CHIKV免疫力缓慢但逐渐积累。巴伊亚仍然是美洲CHIKV遗传多样性的一个储存库，基因组监测策略对于协助监测和了解虫媒病毒在当地和远距离的传播和持久性至关重要。
Between June 2017 and August 2018, several municipalities located in Bahia state (Brazil) reported a large increase in the number of patients presenting with febrile illness similar to that of arboviral infections. Using a combination of portable whole genome sequencing, molecular clock and epidemiological analyses, we revealed the return of the CHIKV-ECSA genotype into Bahia. Our results show local persistence of lineages in some municipalities and the re-introduction of new epidemiological strains from different Brazilian regions, highlighting a complex dynamic of transmission between epidemic seasons and sampled locations. Estimated climate-driven transmission potential of CHIKV remained at similar levels throughout the years, such that large reductions in the total number of confirmed cases suggests a slow, but gradual accumulation of herd-immunity over the 4 years of the epidemic in Bahia after its introduction in 2014. Bahia remains a reservoir of the genetic diversity of CHIKV in the Americas, and genomic surveillance strategies are essential to assist in monitoring and understanding arboviral transmission and persistence both locally and over large distances.