Glutathione depletion and oxidative stress: study with perfused bovine eye.
Glutathione depletion and oxidative stress: study with perfused bovine eye.
复制标题
谷胱甘肽消耗和氧化应激：用灌注牛眼进行研究。
DOI：
10.1089/jop.1985.1.85
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Shichi,H
中科院分区：
文献类型：
--
作者：
Kishida,K;Kodama,T;O'Meara,PD;Shichi,H
A bovine eye perfusion system was developed for detoxification studies. The viability of the system was examined by two criteria: the permeability of the aqueous-blood barrier to protein, and the turnover of aqueous humor formation. Although the usefulness of the system for physiological studies is limited, the bovine eye perfusion system proved to be useful for biochemical studies of detoxification. When the system was perfused with t-butyl hydroperoxide plus the glutathione reductase inhibitor nitrofurantoin, glutathione levels of the ciliary body and iris were markedly reduced. The result was interpreted to suggest that glutathione and its redox cycling may play an important role in cellular defense against oxidative stress.
