The chemotherapy of rodent malaria. LVI. Studies on the development of resistance to natural and synthetic endoperoxides.
The chemotherapy of rodent malaria. LVI. Studies on the development of resistance to natural and synthetic endoperoxides.
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啮齿动物疟疾的化疗。
DOI：
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发表时间：
1999
影响因子：
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通讯作者：
B. Robinson
中科院分区：
文献类型：
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作者：
W. Peters;B. Robinson
对氯喹敏感的伯氏疟原虫 N 和对氯喹耐药的约氏疟原虫 ssp。 NS 受到选择压力，采用“2% 复发技术”，来自青蒿素、青蒿酯、一种双环合成内过氧化物 Ro 41-3823（arteflene 的类似物）或 Fenozan B07（一种合成 1,2,4-三恶烷内过氧化物）。虽然两种寄生虫对青蒿素的耐药性确实发展到中等水平，但对其他化合物仅产生低水平的耐药性或没有耐药性，并且一旦撤回药物选择压力，耐药性寄生虫很容易失去耐药性。这些观察结果的相关性和其他研究人员的经验与一旦广泛使用内过氧化物来对抗多重耐药性恶性疟原虫可能在自然界中产生耐药性的可能风险进行了讨论。
Chloroquine-sensitive Plasmodium berghei N and chloroquine-resistant P. yoelii ssp. NS were exposed to selection pressure, in the '2% relapse technique', from artemisinin, artesunate, a bicyclic, synthetic endoperoxide Ro 41-3823 (an analogue of arteflene) or Fenozan B07, a synthetic 1,2,4-trioxane endoperoxide. Whereas resistance against artemisinin did develop to a moderate level in both parasites, only a low level of resistance or none developed to the other compounds, and resistant parasites readily lost resistance once drug-selection pressure was withdrawn. The relevance of these observations and the experience of other investigators are discussed in relation to the possible risk that resistance may be developed in nature once endoperoxides are deployed widely against multidrug-resistant P. falciparum.