Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
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发表时间：
2009-11
影响因子：
2
通讯作者：
Pingping Xu;Weiping Ye;R. Jen;Shu-Hong Lin;C. Kuo;Young C. Lin
中科院分区：
文献类型：
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作者：
Pingping Xu;Weiping Ye;R. Jen;Shu-Hong Lin;C. Kuo;Young C. Lin
乳腺癌和肥胖之间的分子联系已经研究了很多年。肥胖显著增加了乳腺癌的发病率和发病机会。瘦素主要由脂肪细胞分泌，在乳腺癌的发生发展中起重要作用。肥胖者瘦素表达上调，可促进乳腺癌细胞生长。Zeranol被用作合成代谢生长促进剂，以刺激美国牛肉行业的牛生长。（-）-棉酚是从棉籽中提取的一种天然多酚类化合物，是一种抗癌化学预防剂。材料与方法用玉米赤霉醇、瘦素和（-）-棉酚对MCF-7 Adr细胞生长进行研究。结果Leptin可增强MCF-7Adr细胞对玉米赤霉醇的敏感性，促进细胞生长。暴露于玉米赤霉醇可能导致正常乳腺细胞转化为乳腺癌前细胞。结论肥胖个体发生zeranol诱导的乳腺癌的风险可能更大。
BACKGROUND The molecular links between breast cancer and obesity have been studied for many years. Obesity significantly increases the incidence rate and chance of morbidity of breast cancer. Leptin, mainly secreted by adipocytes, plays an important role in breast cancer development. Leptin expression is up-regulated in obesity and it can promote breast cancer cell growth. Zeranol is used as an anabolic growth promoter to stimulate cattle growth in the U.S. beef industry. (-)-Gossypol, a natural polyphenolic compound extracted from cottonseed, is an anticancer chemopreventive agent. MATERIALS AND METHODS Zeranol, leptin and (-)-gossypol were used to investigate MCF-7 Adr cell growth. RESULTS Leptin enhanced the sensitivity of MCF-7 Adr cells to zeranol and increased cell growth. Exposure to zeranol may lead to initiation of transformation of normal breast cells to breast preneoplastic cells. CONCLUSION It is suggested that obese individuals may be at greater risk of developing zeranol-induced breast cancer.