Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis
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DOI：
10.1177/1352458517748474
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发表时间：
2019-03-01
影响因子：
5.8
通讯作者：
Groppa, Sergiu
中科院分区：
文献类型：
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作者：
Kroth, Julia;Ciolac, Dumitru;Groppa, Sergiu
背景：目前，多发性硬化症 (MS) 患者中不存在疾病演变的明确预测因素。然而，皮质萎缩测量与累积残疾密切相关。目的：在这里，我们的目标是根据脑脊液 (CSF) 标记物预测纵向磁共振成像 (MRI) 驱动的皮质萎缩和临床残疾。方法：我们分析了 CSF 中白蛋白和免疫球蛋白 (Ig) A、G 和 M 的分数及其 CSF 与血清商的比值。结果：广泛的萎缩与基线 CSF 浓度和商的增加高度相关白蛋白和 IgA。 CSFIgA 和 CSFIgM 增加的患者在随访中表现出更高的功能障碍。结论：血脑屏障完整性的 CSF 标记物和特异性免疫反应预测 MS 中出现的灰质病理和疾病进展。
Background: Currently, no unequivocal predictors of disease evolution exist in patients with multiple sclerosis (MS). Cortical atrophy measurements are, however, closely associated with cumulative disability.Objective: Here, we aim to forecast longitudinal magnetic resonance imaging (MRI)-driven cortical atrophy and clinical disability from cerebrospinal fluid (CSF) markers.Methods: We analyzed CSF fractions of albumin and immunoglobulins (Ig) A, G, and M and their CSF to serum quotients.Results: Widespread atrophy was highly associated with increased baseline CSF concentrations and quotients of albumin and IgA. Patients with increased CSFIgA and CSFIgM showed higher functional disability at follow-up.Conclusion: CSF markers of blood-brain barrier integrity and specific immune response forecast emerging gray matter pathology and disease progression in MS.