Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density
Osteoclastic function is accelerated in male patients with type 2 diabetes mellitus: the preventive role of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG) on the decrease of bone mineral density
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DOI：
10.1016/j.diabres.2004.08.006
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发表时间：
2005-05-01
影响因子：
5.1
通讯作者：
Ishida, H
中科院分区：
文献类型：
--
作者：
Suzuki, K;Kurose, T;Ishida, H
为探讨糖尿病患者骨代谢改变的发病机制，测定了2型糖尿病男性患者和正常对照组的骨矿含量和空腹血清全段甲状旁腺激素（i-PTH）、全段骨钙素（i-OC）、抗酒石酸酸性磷酸酶（TRAP）和破骨细胞生成抑制因子/骨保护素（OCIF/OPG）水平。此外，还同时测定了破骨细胞标志物、I型胶原C端肽（CTx）、脱氧吡啶酚（DPD）和I型胶原N端肽（NTx）的尿液水平。糖尿病患者血清i-PTH和i-OC水平显著低于对照组。相反，TRAP的血清浓度在糖尿病患者中显著升高。然而，血清i-OC和TRAP之间没有观察到明显的相关性。糖尿病患者尿CTx、DPD、NTx排泄量明显高于对照组。出乎意料的是，OCIF/OPG的血清水平在糖尿病组中倾向于更高，并且这些值与血清TRAP的值呈现出显著的正相关。血清TRAP与骨密度（BMD）呈显著负相关，血清OCIF/OPG与骨密度呈显著负相关。OCIF/OPG可能对2型糖尿病患者骨吸收增加有抑制作用，以防止骨骼骨量进一步丢失。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
To clarify the pathogenesis of altered bone metabolism in diabetic state and its underlying mechanisms, the bone mineral content and fasting levels of serum intact parathyroid hormone (i-PTH), intact osteocalcin (i-OC), tartrate-resistant acid phosphatase (TRAP) and osteoclastgenesis inhibitory factor/osteoprotegerin (OCIF/OPG) were measured in male type 2 diabetic patients and their age-matched controls. In addition, urine levels of osteoclastic markers, C-telopeptide of type I collagen (CTx), deoxypyridinoline (DPD), and N-telopeptide of type I collagen (NTx) were simultaneously determined. Serum levels of i-PTH and i-OC in diabetic patients were significantly lower than those in the controls. Conversely, serum concentrations of TRAP were significantly elevated in diabetic patients. However, no clear correlation was observed between serum i-OC and TRAP. It was also observed that urinary excretion of CTx, DPD, and NTx was significantly increased in the diabetics as compared with the controls. Unexpectedly, serum levels of OCIF/OPG tended to be higher in the diabetic group, and these values exhibited a significantly positive correlation with those of serum TRAP. There was found a significantly negative correlation between serum TRAP and bone mineral density (BMD) and also between serum OCIF/OPG and bone mineral density. It seems probable that OCIF/OPG has a suppressive role on the increased bone resorption to prevent further loss of the skeletal bone mass in type 2 diabetic patients. (c) 2004 Elsevier Ireland Ltd. All rights reserved.