Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans
Raman spectroscopy detects distant invasive brain cancer cells centimeters beyond MRI capability in humans
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DOI：
10.1364/boe.7.005129
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发表时间：
2016-12-01
影响因子：
3.4
通讯作者：
Petrecca, Kevin
中科院分区：
文献类型：
--
作者：
Jermyn, Michael;Desroches, Joannie;Petrecca, Kevin
脑癌的手术治疗受到当前成像能力的限制，例如磁共振成像（MRI）无法检测这种局部浸润性癌症的整体。这导致手术后残留的癌细胞，导致复发和死亡。我们证明，术中拉曼光谱可以检测到超出病理T1对比增强和T2加权MRI信号几厘米的浸润性癌细胞。这种术中光导可用于检测侵袭性癌细胞并最大限度地减少术后癌症负担。MRI信号之外的远处浸润癌细胞的检测有可能提高手术的有效性，并直接延长患者的生存期。(C)2016美国光学学会
Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can be used to detect invasive cancer cells and minimize post-surgical cancer burden. The detection of distant invasive cancer cells beyond MRI signal has the potential to increase the effectiveness of surgery and directly lengthen patient survival. (C) 2016 Optical Society of America