Polymer implant materials with improved X-ray opacity and biocompatibility.
Polymer implant materials with improved X-ray opacity and biocompatibility.
复制标题
具有改进的 X 射线不透明度和生物相容性的聚合物植入材料。
DOI：
10.1016/0142-9612(81)90041-7
复制
发表时间：
1981
期刊：
影响因子：
14
通讯作者：
Po
中科院分区：
文献类型：
--
作者：
Po
制备了含有28wt%无机填料（如氧化锆、硫酸钡、氧化锌、氧化镁和磷酸三钙）的聚（甲基丙烯酸甲酯）样品，并通过物理性能测试研究了其作为植入材料的适用性。X射线不透明度测量、细胞培养和动物实验。加入无机填料的聚甲基丙烯酸甲酯的压缩强度增加，但降低了横向强度。氧化锆被认为是最适合作为X射线不透明填料，磷酸三钙显示出上级生物相容性时，加入到聚（甲基丙烯酸甲酯）在细胞培养实验。氧化锆和磷酸三钙复合材料在大鼠中诱发的不良组织反应并不比纯聚（甲基）丙烯酸酯大。从物理和生物学的角度来看，氧化锆是聚（甲基丙烯酸甲酯）植入材料中不透射线的填料，添加磷酸三钙可以改善其生物相容性。
Poly(methyl methacrylate) samples containing 28 wt% inorganic fillers such as zirconium oxide, barium sulphate, zinc oxide, magnesium oxide and tricalcium phosphate were prepared and studied for their suitability as implant materials by physical property tests. X-ray opacity measurement, cell culture, and animal implantations. Addition of inorganic fillers to poly(methyl methacrylate) increased the compressive strength but decreased the transverse strength. Zirconium oxide was found to be most suitable as an X-ray opaque filler, and tricalcium phosphate showed superior biocompatibility when added to poly(methyl methacrylate) in cell culture experiments. The zirconium oxide and tricalcium phosphate composites evoked no greater unfavourable tissue reaction in rats than pure poly(methy) methacrylate). From the physical and biological standpoints zirconium oxide is the radiopaque filler of choice to be incorporated in poly(methyl methacrylate) implant material and addition of tricalcium phosphate could improve it's biocompatibility.