Intraocular tumour necrosis factor ligand related molecule 1 A links disease progression of proliferative diabetic retinopathy after primary vitrectomy
Intraocular tumour necrosis factor ligand related molecule 1 A links disease progression of proliferative diabetic retinopathy after primary vitrectomy
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眼内肿瘤坏死因子配体相关分子1A与原发性玻璃体切除术后增殖性糖尿病视网膜病变的疾病进展有关
DOI：
10.1111/1440-1681.13284
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发表时间：
2020-03-03
影响因子：
2.9
通讯作者：
Yan, Hua
中科院分区：
文献类型：
--
作者：
Wang, Tian;Li, Jianan;Yan, Hua
肿瘤坏死因子配体相关分子1A（TL1A）是肿瘤坏死因子超家族成员之一，是调节血管稳态和炎症的重要因子。然而，TL1A在糖尿病视网膜病变（DR）中的功能在很大程度上是未知的。本研究旨在检测增殖性糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）患者血清和眼内液中TL1A的水平，并探讨眼内TL1A与原发性玻璃体切除术后PDR进展预后的相关性。选择75例（75眼）接受玻璃体切割术（PPV）的PDR患者和19例（19眼）接受玻璃体切割术治疗特发性黄斑裂孔（IMH）的非糖尿病患者作为对照组。在白内障和PPV手术期间收集血清、房水和玻璃体液样品。检测血清和眼内液中TL1A以及其他血管生成和炎性细胞因子的蛋白表达。分析眼内TL1A浓度与炎性细胞因子的相关性。PDR组房水和玻璃体中TL1A水平均显著高于对照组（P房水= 0.026; P玻璃体
Tumour necrosis factor ligand related molecule 1 A (TL1A), a member of tumour necrosis factor superfamily, has been identified as a crucial regulator for vascular homeostasis and inflammation. However, the function of TL1A in diabetic retinopathy (DR) is largely unknown. This study aims to examine levels of TL1A in serum and intraocular fluid in patients with proliferative diabetic retinopathy (PDR), and to explore the correlation of intraocular TL1A with the prognosis of PDR progression after primary vitrectomy. Seventy-five patients (75 eyes) with PDR who underwent pars plana vitrectomy (PPV) and 19 patients (19 eyes) who received vitrectomy for idiopathic macular holes (IMH) as non-diabetic control group were enrolled in this prospective study. Serum, aqueous and vitreous fluid samples were collected during cataract and PPV surgery. Protein expressions of TL1A as well as other angiogenic and inflammatory cytokines in serum and intraocular fluid were measured. Correlations of intraocular TL1A concentrations with inflammatory cytokines were analyzed. We found both aqueous and vitreous TL1A levels were significantly higher in the PDR group than in control group (P-aqueous = 0.026; P-vitreous