Evidence of reproductive failure and lack of perinatal transmission of Bartonella henselae in experimentally infected cats
Evidence of reproductive failure and lack of perinatal transmission of Bartonella henselae in experimentally infected cats
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DOI：
10.1016/s0165-2427(98)00153-6
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发表时间：
1998-10-23
影响因子：
1.8
通讯作者：
HogenEsch, H
中科院分区：
文献类型：
--
作者：
Guptill, L;Slater, LN;HogenEsch, H
将皮内接种亨氏假单胞菌和细菌剂4周的5只雌性SPF猫和1只接种0.9%氯化钠的SPF猫与未感染的SPF公猫饲养。未感染的母猫怀孕了一次，而三只感染的猫在1-12周后怀孕，经过反复繁殖。尽管多次繁殖，但两只受感染的雌性动物要么没有怀孕，要么保持怀孕。感染的猫产生抗B抗体、鸡瘟病毒IgM抗体和免疫球蛋白G抗体。感染的食物中的胎儿和小猫没有感染，也不产生抗B。亨塞莱斯抗体。与受感染的雌性猫繁殖的公猫没有感染或血清转换。产后2周仔猫血清中检测不到母体抗B、亨氏杆菌抗体，产后10周不再检测到母体抗B、亨氏杆菌抗体，提示亨塞氏杆菌可引起母猫繁殖障碍，但不会通过胎盘、初乳、乳汁或性传播途径传播。在小猫断奶后，用甲基强的松龙醋酸酯对受感染的猫进行免疫抑制，在组织中没有检测到细菌，这表明它们不再被感染。(C)1998 Elsevier Science B.V.保留所有权利。
Five female specific pathogen-free (SPF) cats inoculated intradermally with B. henselae and bacteremic for 4 weeks, and one cat inoculated with 0.9% NaCl, were bred with uninfected SPF male cats. The uninfected female became pregnant with one breeding, while three infected cats became pregnant 1-12 weeks later, after repeated breedings. Two infected females either did not become pregnant or maintain pregnancies despite repeated breedings. Infected cats produced anti-B, henselae IgM and IgG antibodies. Fetuses and kittens of infected eats were not infected and did not produce anti-B. henselae antibodies. Male cats bred with infected females did not become infected or seroconvert. Maternal anti-B, henselae IgG antibodies detected in sera of kittens 2 weeks post-partum were no longer detectable 10 weeks post-partum, These findings suggest that B. henselae causes reproductive failure in female cats, but is not transmitted transplacentally, in colostrum or milk, or venereally. Infected cats immunosuppressed with methylprednisolone acetate after their kittens were weaned had no detectable bacteria in tissues, suggesting that they were no longer infected. (C) 1998 Elsevier Science B.V. All rights reserved.